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flupirtine

Known as: ethyl 2-amino-6-((p-fluorobenzyl)amino)-3-pyridinecarbamate, ethyl N-(2-amino-6-((4-fluorophenyl)methylamino)pyridin-3-yl)carbamate, flupirtine [Chemical/Ingredient] 
National Institutes of Health

Related topics

Related topics

7 relations

Broader (2)

AminopyridinesAnalgesics

Narrower (5)

D 9998FLUPIRTINE GLUCONATEFLUPIRTINE MALEATEKatadolon

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2015
2015
Oxidation Potentials of N‐Modified Derivatives of the Analgesic Flupirtine Linked to Potassium KV7 Channel Opening Activity But Not Hepatocyte Toxicity
Openers of neuronal voltage‐gated potassium channels (KV) are of interest as therapeutic agents for treating pain (flupirtine… 
2015
2015
Role of flupirtine as a preemptive analgesic in patients undergoing laparoscopic cholecystectomy
Background and Aims: Postsurgical pain is the leading complaint after laparoscopic cholecystectomy that may delay the… 
Review
2012
Review
2012
The evolving understanding of the analgesic mechanism of action of flupirtine
What is known and Objective:  Flupirtine is a widely known analgesic drug that is approved for the treatment of acute and chronic… 
2011
2011
KV7 channels regulate muscle tone and nonadrenergic noncholinergic relaxation of the rat gastric fundus
2001
2001
Applications of liquid chromatography-tandem mass spectrometry in drug and biomedical analyses.
Review
1999
Review
1999
[Neuronal potassium channel opening with flupirtine].
The spectrum of action of flupirtine includes analgesic, muscle-relaxant and neuroprotective properties. The substance's… 
1997
1997
Flupirtine protects both neuronal cells and lymphocytes against induced apoptosis in vitro: Implications for treatment of AIDS patients
In the present study we demonstrate that flupirtine, an already clinically used, centrally acting, non-opiate analgesic agent… 
Highly Cited
1996
Highly Cited
1996
Protection of rabbit retina from ischemic injury by flupirtine.
PURPOSE The aim of this study was to determine wether flupirtine can slow down the changes seen in the rabbit retina after… 
1994
1994
N-methyl-D-aspartate (NMDA)-mediated muscle relaxant action of flupirtine in rats.
The present study examined in urethane-chloralose anaesthetized rats whether N-methyl-D-aspartate (NMDA) is involved in the… 
1987
1987
Clinical experience with flupirtine in the U.S.
Abstract Flupirtine, a chemically unique, orally effective, non-narcotic, centrally acting analgesic was evaluated for efficacy… 
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