Aminopyridines

Known as: Aminopyridines [Chemical/Ingredient], aminopyridine 
Pyridines substituted in any position with an amino group. May be hydrogenated, but must retain at least one double bond.
National Institutes of Health

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Topic mentions per year

1938-2017
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2011
2011
The contribution of neuronal dysfunction to neurodegeneration is studied in a mouse model of spinocerebellar ataxia type 1 (SCA1… (More)
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2009
2009
Aminopyridines such as 4-aminopyridine (4-AP) are widely used as voltage-activated K(+) (Kv) channel blockers and can improve… (More)
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2008
2008
Downbeat nystagmus (DBN) is the most frequent form of acquired persisting fixation nystagmus. It is hypothesized to occur when… (More)
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2001
2001
Previous studies suggest that aminopyridine may play a role in the symptomatic treatment of fatigue in multiple sclerosis… (More)
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Highly Cited
1995
Highly Cited
1995
Acquired neuromyotonia is characterized by hyperexcitability of motor nerves leading to muscle twitching, cramps, and weakness… (More)
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Highly Cited
1994
Highly Cited
1994
Voltage-dependent K+ currents were characterized using the patch-clamp technique in smooth muscle cells isolated from rabbit… (More)
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1990
1990
The blocking action of aminopyridines on an inactivating K current (lKi) in GH3 pituitary cells was studied before and after… (More)
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Highly Cited
1982
Highly Cited
1982
The blocking action of 4-aminopyridine (4-AP) and 3, 4-diaminopyridine (Di-AP) on transient potassium current (IA) in molluscan… (More)
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1976
1976
The effects of aminopyridines on ionic conductances of the squid giant axon membrane were examined using voltage clamp and… (More)
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Highly Cited
1976
Highly Cited
1976
Aminopyridines (2-AP, 3-AP, and 4-AP) selectively block K channels of squid axon membranes in a manner dependent upon the… (More)
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