fibrillin-1

Known as: fbn1, fibrillin-1 (FBN1), Fibrillin-1 [Chemical/Ingredient] 
A fibrillin (FBN1) that functions as a structural support protein for MICROFIBRILS. It also regulates the maturation of OSTEOBLASTS by controlling… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1986-2018
020406019862018

Papers overview

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Highly Cited
2010
Highly Cited
2010
The predisposition for scleroderma, defined as fibrosis and hardening of the skin, is poorly understood. We report that stiff… (More)
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Highly Cited
2007
Highly Cited
2007
We have discovered that fibrillin-1, which forms extracellular microfibrils, can regulate the bioavailability of transforming… (More)
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Highly Cited
2006
Highly Cited
2006
Aortic aneurysm and dissection are manifestations of Marfan syndrome (MFS), a disorder caused by mutations in the gene that… (More)
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Highly Cited
2003
Highly Cited
2003
Latent transforming growth factor beta-binding protein 1 (LTBP-1) targets latent complexes of transforming growth factor beta to… (More)
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Highly Cited
2003
Highly Cited
2003
Weill-Marchesani syndrome (WMS) is a connective tissue disorder characterised by short stature, brachydactyly, joint stiffness… (More)
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Highly Cited
2002
Highly Cited
2002
Fibrillin-containing microfibrils are polymeric structures that are difficult to extract from connective tissues. Proteolytic… (More)
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Highly Cited
1999
Highly Cited
1999
Dissecting aortic aneurysm is the hallmark of Marfan syndrome (MFS) and the result of mutations in fibrillin-1, the major… (More)
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Highly Cited
1999
Highly Cited
1999
Fibrillin is the principal structural component of the 10-12 nm diameter elastic microfibrils of the extracellular matrix. We… (More)
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Highly Cited
1997
Highly Cited
1997
Aortic aneurysm and dissection account for about 2% of all deaths in industrialized countries; they are also components of… (More)
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Highly Cited
1995
Highly Cited
1995
Extracellular microfibrils, alone or in association with elastin, confer critical biomechanical properties on a variety of… (More)
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