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Latent Transforming Growth Factor β-binding Protein 1 Interacts with Fibrillin and Is a Microfibril-associated Protein*
Immunolocalization data were consistent with the hypothesis that LTBP-1 is a fibrillin-associated protein present in certain tissues but not in others, and a model depicting the relationship between LT BP-1 and fibrillins microfibrils is proposed.
The conduit system transports soluble antigens from the afferent lymph to resident dendritic cells in the T cell area of the lymph node.
Fibrillin assembly requires fibronectin.
- L. Sabatier, Daliang Chen, D. Reinhardt
- Biology, MedicineMolecular biology of the cell
- 26 November 2008
Human dermal fibroblasts are used to analyze the assembly of fibrillin-1 in dependence of other matrix-forming proteins and mapping studies revealed that the major binding interaction between fibrillins and fibronectin involves the collagen/gelatin-binding region between domains FNI(6) and F NI(9).
Fibrillins: from biogenesis of microfibrils to signaling functions.
Fibrillin-1: organization in microfibrils and structural properties.
Comparison of distances between antibody binding sites on the recombinant peptides and labeling events in tissue suggests that fibrillin molecules are compacted within their tissue form as microfibrils, and additional analysis of the peptides provide new information regarding the eight-cysteine motif, a novel domain present in fibrillins and TGF beta binding proteins, and suggest that fBRs are processed at their N-and C-terminal ends.
Targetting of the gene encoding fibrillin–1 recapitulates the vascular aspect of Marfan syndrome
A gene-targetting experiment in mice indicates that fibrillin-1 microfibrils are predominantly engaged in tissue homeostasis rather than elastic matrix assembly, which suggests that aortic dilation is due primarily to the failure by themicrofibrillar array of the adventitia to sustain physiological haemodynamic stress, and that disruption of the elastic network of the media is a secondary event.
A New Model of Development of the Mammalian Ovary and Follicles
A novel cell type is identified, termed GREL for Gonadal Ridge Epithelial-Like, which is believed to penetrate into the ovary and develop into granulosa cells when associating with oogonia to form follicles, in contrast to the prevailing theory.
Interactions of Fibrillin-1 with Heparin/Heparan Sulfate, Implications for Microfibrillar Assembly*
- K. Tiedemann, B. Bätge, P. Müller, D. Reinhardt
- Biology, ChemistryThe Journal of Biological Chemistry
- 21 September 2001
It is suggested that binding of fibrillin-1 to proteoglycan-associated heparan sulfate chains is an important step in the assembly of microfibrils.
Immunophenotyping of the human bulge region: the quest to define useful in situ markers for human epithelial hair follicle stem cells and their niche
This study critically evaluating corresponding published immunoreactivity (IR) patterns, and by attempting to identify markers for the in situ identification of human eHFSCs and their niche, attempts to define useful markers.
Homo- and Heterotypic Fibrillin-1 and -2 Interactions Constitute the Basis for the Assembly of Microfibrils*
It is demonstrated that fibrillins can directly interact in an N- to C-terminal fashion to form homotypic fibrillin-1 or heterotypic F1/F2 microfibrils, and the binding epitopes as well as the entirefibrillin molecules displayed very stable properties.