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Collagens at a glance
Collagens are a large family of triple helical proteins that are widespread throughout the body and are important for a broad range of functions, including tissue scaffolding, cell adhesion, cell
Assembly of fibrillin microfibrils governs extracellular deposition of latent TGFβ
Control of the bioavailability of the growth factor TGFβ is essential for tissue formation and homeostasis, yet precisely how latent TGFβ is incorporated into the extracellular matrix is unknown.
The molecular genetics of Marfan syndrome and related disorders
Marfan syndrome (MFS), a relatively common autosomal dominant hereditary disorder of connective tissue with prominent manifestations in the skeletal, ocular, and cardiovascular systems, is caused by
Fibrillin microfibrils are stiff reinforcing fibres in compliant tissues.
Missense mutations that cause Van der Woude syndrome and popliteal pterygium syndrome affect the DNA-binding and transcriptional activation functions of IRF6
The sequence to which IRF6 binds is determined and this sequence is used to analyse the effect of VWS- and PPS-associated mutations in the DNA-binding domain of IRf6 and it is demonstrated that IRF 6 functions as a co-operative transcriptional activator and that mutations inThe protein interaction domain ofIRF6 disrupt this activity.
A Mechanism of Drug Action Revealed by Structural Studies of Enoyl Reductase
Analysis of the structures of complexes of Escherichia coli ENR with nicotinamide adenine dinucleotide and either thienodiazaborine or benzodiazabadine revealed the formation of a covalent bond between the 2′ hydroxyl of the nicotinamia ribose and a boron atom in the drugs to generate a tight, noncovalently bound bisubstrate analog.
Shape of tropoelastin, the highly extensible protein that controls human tissue elasticity
This study solves the nanostructure of full-length and corresponding overlapping fragments of tropoelastin using small angle X-ray and neutron scattering, allowing us to identify discrete regions of the molecule.
Differential Regulation of Elastic Fiber Formation by Fibulin-4 and -5*
A molecular account of the distinct roles of fibulin-4 and -5 in elastic fiber assembly and how they act in concert to chaperone cross-linked elastin onto microfibrils is provided.
The Angiogenic Inhibitor Long Pentraxin PTX3 Forms an Asymmetric Octamer with Two Binding Sites for FGF2*
Biophysical analyses reveal that PTX3 is composed of eight identical protomers, associated through disulfide bonds, forming an elongated and asymmetric, molecule with two differently sized domains interconnected by a stalk, explaining both its quaternary organization and how this is required for its antiangiogenic function.