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ethoxidine

Known as: 12-ethoxy-2,3,8,9-tetramethoxy-5-methyl-benzo(c)phenanthridinium 
National Institutes of Health

Related topics

Related topics

2 relations

Broader (2)

PhenanthridinesTopoisomerase I Inhibitors

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
Pro-Angiogenic Effects of Low Dose Ethoxidine in a Murine Model of Ischemic Hindlimb: Correlation between Ethoxidine Levels and Increased Activation of the Nitric Oxide Pathway
Ethoxidine, a benzo[c]phenanthridine derivative, has been identified as a potent inhibitor of topoisomerase I in cancer cell… 
2010
2010
Paradoxical effects of the topoisomerase inhibitor, ethoxidine, in the cellular processes leading to angiogenesis on EaHy.926 endothelial cells
to the genome. this enzyme is the target for some of the most successful anticancer drugs. Ethoxidine, a benzo[c]phenanthridines… 
2007
2007
Exploring DNA topoisomerase I inhibition by the benzo[c]phenanthridines fagaronine and ethoxidine using steered molecular dynamics.
2004
2004
In vitro metabolism of ethoxidine by human CYP1A1 and rat microsomes: identification of metabolites by high-performance liquid chromatography combined with electrospray tandem mass spectrometry and…
Ethoxidine (N-methyl-12-ethoxy-2,3,8,9-tetramethoxybenzo[c]phenanthridinium methylsulfonate salt) is a synthetic 2-methoxy-12… 
Highly Cited
2001
Highly Cited
2001
Synthesis, biological activity and comparative analysis of DNA binding affinities and human DNA topoisomerase I inhibitory activities of novel 12-alkoxy-benzo[c]phenanthridinium salts.
Highly Cited
2000
Highly Cited
2000
Molecular Determinants of Site-specific Inhibition of Human DNA Topoisomerase I by Fagaronine and Ethoxidine
DNA topoisomerase (top) I inhibition activity of the natural alkaloid fagaronine (NSC157995) and its new synthetic derivative… 
1999
1999
Combined SERS and flow linear dichroism approach to monitoring the interaction of pharmaceuticals with their target
Surface-Enhanced Raman Scattering (SERS) spectroscopy and Flow Linear Dichroism (FLD) technique have been employed to study the… 
Review
1998
Review
1998
Biochemistry: The Role of the Iminium Bond in the Inhibition of Reverse Transcriptase by Quaternary Benzophenanthridines
The quaternary benzo[c]phenanthridines fagaronine, nitidine and O‐methylfagaronine have been reviewed as potential antitumour and… 
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