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Potent antimalarial activity of the alkaloid nitidine, isolated from a Kenyan herbal remedy.
Bioassay-guided fractionation of extracts of Toddalia asiatica, a plant used by the Pokot tribe of Kenya to treat fevers, has yielded the alkaloid nitidine as the major antimalarial component.Expand
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Antimicrobial activity of pentacyclic triterpenes isolated from African Combretaceae.
Four pentacyclic tritepenes were isolated from Combretum imberbe Engl. & Diels, of which two are novel glycosidic derivatives of 1alpha,3beta,23-trihydroxyolean-12-en-29-oic acid (hydroxyimberbicExpand
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Chemical reactivity of some isothiazolone biocides.
Chemical reactions between the isothiazolone biocides, N-methylisothiazol-3-one (MIT), benzisothiazol-3-one (BIT) and 5-chloro-N-methylisothiazol-3-one (CMIT) with cysteine have been investigated byExpand
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Natural Products as Leads for New Pharmaceuticals
A review of the use of natural products as starting points in the search for new pharmaceuticals, covering the broad areas of “Drugs affecting the centeral nervous system, ” “Neuromuscular blockingExpand
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Antibacterial action of 2-bromo-2-nitropropane-1,3-diol (bronopol).
Patterns of growth inhibition of Escherichia coli in the presence of 2-bromo-2-nitropropane-1,3-diol (bronopol) indicate a period of biocide-induced bacteriostasis followed by growth at an inhibitedExpand
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Antimicrobial lexitropsins containing amide, amidine, and alkene linking groups.
The synthesis and properties of 80 short minor groove binders related to distamycin and the thiazotropsins are described. The design of the compounds was principally predicated upon increasedExpand
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Quaternary ammonium palmitoyl glycol chitosan--a new polysoap for drug delivery.
A new polysoap, quaternary ammonium palmitoyl glycol chitosan (GCPQ, M(w)=178,000 g mole(-1)) with drug solubilising potential has been synthesised and characterised. In solution hydrophobic domainsExpand
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Calystegines in Solanum and Datura species and the death's-head hawk-moth (Acherontia atropus)
Abstract Polyhydroxylated tropane alkaloids, not hitherto recorded from the potato ( Solanum tuberosum ), were detected in the leaves and tubers of this plant. They are potent inhibitors ofExpand
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Mechanisms underlying the metabolic actions of galegine that contribute to weight loss in mice
Background and purpose: Galegine and guanidine, originally isolated from Galega officinalis, led to the development of the biguanides. The weight‐reducing effects of galegine have not previously beenExpand
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