R. Waigh

Publications200
h-index26
Citations2,470
Highly Influential Citations51
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Potent antimalarial activity of the alkaloid nitidine, isolated from a Kenyan herbal remedy
TLDR
Bioassay-guided fractionation of extracts of Toddalia asiatica, a plant used by the Pokot tribe of Kenya to treat fevers, has yielded the alkaloid nitidine as the major antimalarial component, and results show a lack of cross-resistance between chloroquine and nitidine.
Chemical reactivity of some isothiazolone biocides.
TLDR
NMR spectral studies indicated that for CMIT the mercaptoacrylamide form is capable of tautomerization to a highly reactive thio-acyl chloride, which is suggested to account for much of this enhanced antimicrobial activity.
Antimicrobial activity of pentacyclic triterpenes isolated from African Combretaceae.
Four pentacyclic tritepenes were isolated from Combretum imberbe Engl. & Diels, of which two are novel glycosidic derivatives of 1alpha,3beta,23-trihydroxyolean-12-en-29-oic acid (hydroxyimberbic…
Calystegines in Solanum and Datura species and the death's-head hawk-moth (Acherontia atropus)
TLDR
Polyhydroxylated tropane alkaloids, not hitherto recorded from the potato, were detected in the leaves and tubers of this plant and may be responsible for neurological disorders in livestock.
Natural Products as Leads for New Pharmaceuticals
A review of the use of natural products as starting points in the search for new pharmaceuticals, covering the broad areas of “Drugs affecting the centeral nervous system, ” “Neuromuscular blocking…
Antibacterial action of 2-bromo-2-nitropropane-1,3-diol (bronopol)
Patterns of growth inhibition of Escherichia coli in the presence of 2-bromo-2-nitropropane-1,3-diol (bronopol) indicate a period of biocide-induced bacteriostasis followed by growth at an inhibited…
Quaternary ammonium palmitoyl glycol chitosan--a new polysoap for drug delivery.
TLDR
A new biocompatible polysoap (potential drugsolubiliser) is described which forms hydrophobic domains in solution and shows hysteresis in its solubilisation of pyrene.
Mechanisms underlying the metabolic actions of galegine that contribute to weight loss in mice
TLDR
The weight‐reducing effects of galegine have not previously been studied and the present investigation was undertaken to determine its mechanism(s) of action.
Phytochemical and antimicrobial investigations of stilbenoids and flavonoids isolated from three species of Combretaceae.
TLDR
From this study it was evident that most stilbenoids and flavonoids from the selected Combretaceae have little or no antimicrobial activity.
Secoiridoid and triterpenic acids from the stems of Nauclea diderrichii
Abstract The stem bark of Nauclea diderrichii has yielded diderroside, a new secoiridoid glucoside, as well as quinovic acid, 3-oxoquinovic acid and 3- O -glucosylquinovic acid. The hydrocarbon…
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