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- Publications
- Influence
Potent antimalarial activity of the alkaloid nitidine, isolated from a Kenyan herbal remedy.
- D. M. Gakunju, E. Mberu, +4 authors W. Watkins
- Biology, Medicine
- Antimicrobial agents and chemotherapy
- 1 December 1995
Bioassay-guided fractionation of extracts of Toddalia asiatica, a plant used by the Pokot tribe of Kenya to treat fevers, has yielded the alkaloid nitidine as the major antimalarial component.… Expand
Antimicrobial activity of pentacyclic triterpenes isolated from African Combretaceae.
- D. Katerere, A. Gray, R. Nash, R. Waigh
- Biology, Medicine
- Phytochemistry
- 1 May 2003
Four pentacyclic tritepenes were isolated from Combretum imberbe Engl. & Diels, of which two are novel glycosidic derivatives of 1alpha,3beta,23-trihydroxyolean-12-en-29-oic acid (hydroxyimberbic… Expand
Chemical reactivity of some isothiazolone biocides.
- P. Collier, A. Ramsey, R. Waigh, K. T. Douglas, P. Austin, P. Gilbert
- Chemistry, Medicine
- The Journal of applied bacteriology
- 1 October 1990
Chemical reactions between the isothiazolone biocides, N-methylisothiazol-3-one (MIT), benzisothiazol-3-one (BIT) and 5-chloro-N-methylisothiazol-3-one (CMIT) with cysteine have been investigated by… Expand
Natural Products as Leads for New Pharmaceuticals
- A. D. Buss, B. Cox, R. Waigh
- Chemistry
- 15 January 2003
A review of the use of natural products as starting points in the search for new pharmaceuticals, covering the broad areas of “Drugs affecting the centeral nervous system, ” “Neuromuscular blocking… Expand
An insecticidal quassinoid from the new Australian species Quassia sp. aff. bidwillii.
- Z. Latif, L. A. Craven, +5 authors P. Waterman
- Biology
- 1 March 2000
Antibacterial action of 2-bromo-2-nitropropane-1,3-diol (bronopol).
- J. A. Shepherd, R. Waigh, P. Gilbert
- Chemistry, Medicine
- Antimicrobial Agents and Chemotherapy
- 1 November 1988
Patterns of growth inhibition of Escherichia coli in the presence of 2-bromo-2-nitropropane-1,3-diol (bronopol) indicate a period of biocide-induced bacteriostasis followed by growth at an inhibited… Expand
Antimicrobial lexitropsins containing amide, amidine, and alkene linking groups.
- N. Anthony, D. Breen, +11 authors R. Waigh
- Chemistry, Medicine
- Journal of medicinal chemistry
- 26 October 2007
The synthesis and properties of 80 short minor groove binders related to distamycin and the thiazotropsins are described. The design of the compounds was principally predicated upon increased… Expand
Quaternary ammonium palmitoyl glycol chitosan--a new polysoap for drug delivery.
- I. Uchegbu, L. Sadiq, +4 authors A. Schätzlein
- Chemistry, Medicine
- International journal of pharmaceutics
- 1 December 2000
A new polysoap, quaternary ammonium palmitoyl glycol chitosan (GCPQ, M(w)=178,000 g mole(-1)) with drug solubilising potential has been synthesised and characterised. In solution hydrophobic domains… Expand
Calystegines in Solanum and Datura species and the death's-head hawk-moth (Acherontia atropus)
- R. Nash, R. Nash, +4 authors P. Waterman
- Biology
- 1 November 1993
Abstract Polyhydroxylated tropane alkaloids, not hitherto recorded from the potato ( Solanum tuberosum ), were detected in the leaves and tubers of this plant. They are potent inhibitors of… Expand
Mechanisms underlying the metabolic actions of galegine that contribute to weight loss in mice
- M. H. Mooney, S. Fogarty, +9 authors B. Furman
- Biology, Medicine
- British journal of pharmacology
- 1 April 2008
Background and purpose: Galegine and guanidine, originally isolated from Galega officinalis, led to the development of the biguanides. The weight‐reducing effects of galegine have not previously been… Expand