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Both Ca2+ and Zn2+ are essential for S100A12 protein oligomerization and function
The present work highlighted the potential role of calcium-binding S100 proteins in zinc metabolism and, in particular, the role of S100A12 in the cross talk between zinc and calcium in cell signaling.
Improved detection limits of protein optical fiber biosensors coated with gold nanoparticles.
Imaging nanometer domains of β-adrenergic receptor complexes on the surface of cardiac myocytes
- A. Ianoul, Donna Grant, Yanouchka Rouleau, M. Bani‐Yaghoub, L. Johnston, J. Pezacki
- BiologyNature chemical biology
- 1 September 2005
For the first time, the ability of near-field scanning optical microscopy to visualize β-adrenergic receptors at the nanoscale in situ is demonstrated and a lower limit for the number of receptors in the signalosome is established.
Steady-State and Transient Ultraviolet Resonance Raman Spectrometer for the 193–270 nm Spectral Region
- S. Bykov, I. Lednev, A. Ianoul, A. Mikhonin, C. Munro, S. Asher
- Chemistry, PhysicsApplied spectroscopy
- 1 December 2005
A new charge-coupled device (CCD) camera that responds efficiently to UV light, as opposed to the previous CCD and photodiode detectors, which required intensifiers for detecting UV light.
Near-field scanning fluorescence microscopy study of ion channel clusters in cardiac myocyte membranes.
- A. Ianoul, M. Street, Donna Grant, J. Pezacki, R. Taylor, L. Johnston
- BiologyBiophysical journal
- 1 November 2004
The ability to quantitatively measure small clusters of ion channels will facilitate future studies that examine changes in protein localization in stimulated cells and during cardiac development and illustrates the potential of NSOM for studying membrane domains and protein localization/colocalization on a length scale which exceeds that available with optical microscopy.
Ganglioside partitioning and aggregation in phase-separated monolayers characterized by bodipy GM1 monomer/dimer emission.
- O. Coban, M. Burger, Mike Laliberte, A. Ianoul, L. Johnston
- ChemistryLangmuir : the ACS journal of surfaces and…
- 4 May 2007
The results demonstrate the complexity of GM1 partitioning and illustrate the utility of complementary AFM and high spatial resolution two-color fluorescence experiments for understanding Bodipy GM1 aggregation and distribution.
Investigating the effects of L- to D-amino acid substitution and deamidation on the activity and membrane interactions of antimicrobial peptide anoplin.
Near‐field scanning optical microscopy probes: a comparison of pulled and double‐etched bent NSOM probes for fluorescence imaging of biological samples
The images obtained with the double‐etched probes show excellent spatial resolution and signal/noise, illustrating the potential of such probes for imaging of biological samples.
Phase Separation in Supported Phospholipid Bilayers Visualized by Near-Field Scanning Optical Microscopy in Aqueous Solution
An experimental approach for near-field scanning optical microscopy (NSOM) of biological samples in an aqueous environment with a resolution of <100 nm has been developed. This was accomplished by…
Optimizing Refractive Index Sensitivity of Supported Silver Nanocube Monolayers
The refractive index (RI) sensitivity of extinction spectra was compared experimentally for silver nanocubes in solution and in supported monolayers prepared by the Langmuir technique. The size of…