eribulin

Known as: halichrondrin B analog, 2-(3-amino-2-hydroxypropyl)hexacosahydro-3-methoxy-26-methyl-20,27-bis(methylene)11,15-18,21-24,28-triepoxy-7,9-ethano-12,15-methano-9H,15H-furo(3,2-i)furo(2',3'-5,6)pyrano(4,3-b)(1,4)dioxacyclopentacosin-5-(4H)-one, 2-(3-Amino-2-hydroxypropyl)hexacosahydro-3-methoxy- 26-methyl-20,27-bis(methylene)11,15-18,21-24,28-triepoxy- 7,9-ethano-12,15-methano-9H,15H-furo(3,2-i)furo(2',3'-5,6) pyrano(4,3-b)(1,4)dioxacyclopentacosin-5-(4H)-one 
An analogue of halichondrin B, a substance derived from a marine sponge (Lissodendoryx sp.) with antineoplastic activity. Eribulin binds to the vinca… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1990-2017
05019902017

Papers overview

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Highly Cited
2016
Highly Cited
2016
BACKGROUND A non-randomised, phase 2 study showed activity and tolerability of eribulin in advanced or metastatic soft-tissue… (More)
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Highly Cited
2015
Highly Cited
2015
PURPOSE This phase III randomized trial (ClinicalTrials.gov identifier: NCT00337103) compared eribulin with capecitabine in… (More)
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Highly Cited
2011
Highly Cited
2011
BACKGROUND Treatments with survival benefit are greatly needed for women with heavily pretreated metastatic breast cancer… (More)
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Highly Cited
2010
Highly Cited
2010
Eribulin mesylate (E7389), a synthetic analogue of the marine natural product halichondrin B, is in phase III clinical trials for… (More)
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Highly Cited
2008
Highly Cited
2008
Eribulin (E7389), a synthetic analogue of halichondrin B in phase III clinical trials for breast cancer, binds to tubulin and… (More)
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Highly Cited
2006
Highly Cited
2006
New antitunor polyether macrolides were successfully isolated fron a marine sponge, Halichondria okadai Kadota. One of them… (More)
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Highly Cited
2005
Highly Cited
2005
E7389, which is in phase I and II clinical trials, is a synthetic macrocyclic ketone analogue of the marine sponge natural… (More)
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Highly Cited
2004
Highly Cited
2004
E7389, a macrocyclic ketone analog of the marine natural product halichondrin B, currently is undergoing clinical trials for… (More)
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Highly Cited
2001
Highly Cited
2001
Halichondrin B is a highly potent anticancer agent originally found in marine sponges. Although scarcity of the natural product… (More)
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Highly Cited
1991
Highly Cited
1991
Data generated in the new National Cancer Institute drug evaluation program, which is based on inhibition of cell growth in 60… (More)
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