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eribulin

Known as: halichrondrin B analog, 2-(3-amino-2-hydroxypropyl)hexacosahydro-3-methoxy-26-methyl-20,27-bis(methylene)11,15-18,21-24,28-triepoxy-7,9-ethano-12,15-methano-9H,15H-furo(3,2-i)furo(2',3'-5,6)pyrano(4,3-b)(1,4)dioxacyclopentacosin-5-(4H)-one, 2-(3-Amino-2-hydroxypropyl)hexacosahydro-3-methoxy- 26-methyl-20,27-bis(methylene)11,15-18,21-24,28-triepoxy- 7,9-ethano-12,15-methano-9H,15H-furo(3,2-i)furo(2',3'-5,6) pyrano(4,3-b)(1,4)dioxacyclopentacosin-5-(4H)-one 
An analogue of halichondrin B, a substance derived from a marine sponge (Lissodendoryx sp.) with antineoplastic activity. Eribulin binds to the vinca… Expand
National Institutes of Health

Papers overview

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2016
2016
Microtubules are dynamic polymers built of tubulin dimers that attach in a head-to-tail fashion to form protofilaments, which… Expand
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Highly Cited
2013
Highly Cited
2013
Chemotherapy-induced peripheral neuropathy (CIPN) is a serious, painful and dose-limiting side effect of cancer drugs that target… Expand
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2013
2013
BACKGROUND Antimitotic agents are essential components for curative therapy of pediatric acute leukemias and many solid tumors… Expand
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Review
2012
Review
2012
Triple-negative breast cancer (TNBC) is an aggressive histological subtype with limited treatment options and very poor prognosis… Expand
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Highly Cited
2011
Highly Cited
2011
Eribulin (E7389), a mechanistically unique microtubule inhibitor in phase III clinical trials for cancer, exhibits superior… Expand
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Highly Cited
2008
Highly Cited
2008
Eribulin (E7389), a synthetic analogue of halichondrin B in phase III clinical trials for breast cancer, binds to tubulin and… Expand
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Highly Cited
2005
Highly Cited
2005
E7389, which is in phase I and II clinical trials, is a synthetic macrocyclic ketone analogue of the marine sponge natural… Expand
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Review
1999
Review
1999
An assessment of the current status of marine anticancer compounds is presented along with a case study on the aquaculture of… Expand
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Review
1992
Review
1992
  • Ernest Hamel
  • Pharmacology & therapeutics
  • 1992
  • Corpus ID: 44835820
This paper summarizes published data on the interactions of tubulin with antimitotic compounds that inhibit the binding of vinca… Expand
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