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Microtubules as a target for anticancer drugs
Highly dynamic mitotic-spindle microtubules are among the most successful targets for anticancer therapy. Microtubule-targeted drugs, including paclitaxel and Vinca alkaloids, were previously… Expand
Microtubule-binding agents: a dynamic field of cancer therapeutics
Microtubules are dynamic filamentous cytoskeletal proteins composed of tubulin and are an important therapeutic target in tumour cells. Agents that bind to microtubules have been part of the… Expand
Mechanism of mitotic block and inhibition of cell proliferation by taxol at low concentrations.
- M. Jordan, R. Toso, D. Thrower, L. Wilson
- Biology, Medicine
- Proceedings of the National Academy of Sciences…
- 15 October 1993
Taxol inhibited HeLa cell proliferation by inducing a sustained mitotic block at the metaphase/anaphase boundary. Half-maximal inhibition of cell proliferation occurred at 8 nM taxol, and mitosis was… Expand
Effects of vinblastine, podophyllotoxin and nocodazole on mitotic spindles. Implications for the role of microtubule dynamics in mitosis.
Inhibition of mitosis by many drugs that bind to tubulin has been attributed to depolymerization of microtubules. However, we found previously that low concentrations of vinblastine and vincristine… Expand
Mitotic block induced in HeLa cells by low concentrations of paclitaxel (Taxol) results in abnormal mitotic exit and apoptotic cell death.
- M. Jordan, K. Wendell, S. Gardiner, W. Derry, H. Copp, L. Wilson
- Biology, Medicine
- Cancer research
- 15 February 1996
Paclitaxel at low concentrations (10 nM for 20 h) induces approximately 90% mitotic block at the metaphase/anaphase transition in HeLa cells, apparently by suppressing dynamics of spindle… Expand
Taxol suppresses dynamics of individual microtubules in living human tumor cells.
Microtubules are intrinsically dynamic polymers, and their dynamics play a crucial role in mitotic spindle assembly, the mitotic checkpoint, and chromosome movement. We hypothesized that, in living… Expand
Substoichiometric binding of taxol suppresses microtubule dynamics.
We have measured the effects of taxol (10 nM to 1 microM) on the growing and shortening dynamics at the ends of individual bovine brain microtubules in vitro and have correlated the effects both with… Expand
Mechanism of action of antitumor drugs that interact with microtubules and tubulin.
- M. Jordan
- Current medicinal chemistry. Anti-cancer agents
Microtubules, major structural components in cells, are the target of a large and diverse group of natural product anticancer drugs. Given the success of this class of drugs in cancer treatment, it… Expand
Microtubules and actin filaments: dynamic targets for cancer chemotherapy.
Microtubules and actin filaments play important roles in mitosis, cell signaling, and motility. Thus these cytoskeletal filaments are the targets of a growing number of anti-cancer drugs. In this… Expand
Mechanism of inhibition of cell proliferation by Vinca alkaloids.
We have used a structure-activity approach to investigate whether the Vinca alkaloids inhibit cell proliferation primarily by means of their effects on mitotic spindle microtubules or by another… Expand