Microtubules as a target for anticancer drugs
Highly dynamic mitotic-spindle microtubules are among the most successful targets for anticancer therapy, and it is now known that at lower concentrations, microtubule-targeted drugs can suppress micro Tubule dynamics without changingmicrotubule mass; this action leads to mitotic block and apoptosis.
Microtubule-binding agents: a dynamic field of cancer therapeutics
- C. Dumontet, M. Jordan
- BiologyNature reviews. Drug discovery
- 1 October 2010
The screening of a range of botanical species and marine organisms has yielded promising new antitubulin agents with novel properties, and the three main objectives are enhanced tumour specificity, reduced neurotoxicity and insensitivity to chemoresistance mechanisms.
Mechanism of mitotic block and inhibition of cell proliferation by taxol at low concentrations.
- M. Jordan, R. Toso, D. Thrower, L. Wilson
- BiologyProceedings of the National Academy of Sciences…
- 15 October 1993
The results indicate that taxol shares a common antiproliferative mechanism with vinblastine, and at its lowest effective concentrations, taxol appears to block mitosis by kinetically stabilizing spindle microtubules and not by changing the mass of polymerizedmicrotubules.
Effects of vinblastine, podophyllotoxin and nocodazole on mitotic spindles. Implications for the role of microtubule dynamics in mitosis.
- M. Jordan, D. Thrower, L. Wilson
- BiologyJournal of Cell Science
- 1 July 1992
The data suggest that these anti-mitotic drugs block mitosis primarily by inhibiting the dynamics of spindle micro Tubules rather than by simply depolymerizing the microtubules.
Taxol suppresses dynamics of individual microtubules in living human tumor cells.
- A. Yvon, P. Wadsworth, M. Jordan
- BiologyMolecular Biology of the Cell
- 1 April 1999
The results indicate that suppression of microtubule dynamics by taxol deleteriously affects the ability of cancer cells to properly assemble a mitotic spindle, pass the metaphase/anaphase checkpoint, and produce progeny.
Mitotic block induced in HeLa cells by low concentrations of paclitaxel (Taxol) results in abnormal mitotic exit and apoptotic cell death.
- M. Jordan, K. Wendell, S. Gardiner, W. B. Derry, H. Copp, L. Wilson
- Biology, ChemistryCancer Research
- 15 February 1996
The results support the hypothesis that the most potent chemotherapeutic mechanism of paclitaxel is kinetic stabilization of spindle microtubule dynamics.
Mechanism of action of antitumor drugs that interact with microtubules and tubulin.
- M. Jordan
- BiologyCurrent Medicinal Chemistry - Anti-Cancer Agents
- 2002
It can be argued that microtubules represent the single best cancer target identified to date, as considerable evidence indicates that, at lower concentrations, these drugs have a common mechanism of action; they suppress the dynamics of micro Tubulin without appreciably changing the mass of microtubule in the cell.
Mechanism of inhibition of cell proliferation by Vinca alkaloids.
- M. Jordan, D. Thrower, L. Wilson
- BiologyCancer Research
- 15 April 1991
It is suggested that the antiproliferative activity of the Vinca alkaloids at their lowest effective concentrations in HeLa cells is due to inhibition of mitotic spindle function, and that specific alterations of spindle microtubule dynamics appear to differ among the five VincA congeners.
Substoichiometric binding of taxol suppresses microtubule dynamics.
- W. B. Derry, L. Wilson, M. Jordan
- BiologyBiochemistry
- 21 February 1995
The data support the hypothesis that binding of a molecule of taxol to a tubulin subunit in microtubules induces a conformational change in that subunit that strongly reduces its ability to dissociate when the subunit becomes exposed at the microtubule end.
The primary antimitotic mechanism of action of the synthetic halichondrin E7389 is suppression of microtubule growth
The results suggest that, at its lowest effective concentrations, E7389 may suppress mitosis by directly binding to microtubule ends as unliganded E7387 or by competition of E7 389-induced tubulin aggregates with unliganding soluble tubulin for addition to growing microtubules ends.
...
...