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E7389

Known as: E 7389, E-7389 
A synthetic analogue of halichondrin B, a substance derived from a marine sponge (Lissodendoryx sp.) with antineoplastic activity. E7389 binds to the… 
National Institutes of Health

Related topics

Related topics

3 relations
ER-086526eribulin mesylate

Broader (1)

eribulin

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2015
2015
Pharmacodynamics (PD) and pharmacokinetics (PK) of E7389 (eribulin, halichondrin B analog) during a phase I trial in patients with advanced solid tumors: a California Cancer Consortium trial
AbstractBackground The California Cancer Consortium completed a phase I trial of E7389 (eribulin mesylate), an analog of the… 
Highly Cited
2010
Highly Cited
2010
Phase III trials of eribulin mesylate (E7389) in extensively pretreated patients with locally recurrent or metastatic breast cancer.
Eribulin mesylate (E7389) is a nontaxane microtubule dynamics inhibitor with a novel mechanism of action. In preclinical studies… 
Highly Cited
2009
Highly Cited
2009
A Phase I Study of Eribulin Mesylate (E7389), a Mechanistically Novel Inhibitor of Microtubule Dynamics, in Patients with Advanced Solid Malignancies
Purpose: Eribulin mesylate (E7389), a non-taxane microtubule dynamics inhibitor, is a structurally simplified, synthetic analogue… 
Highly Cited
2009
Highly Cited
2009
New syntheses of E7389 C14-C35 and halichondrin C14-C38 building blocks: reductive cyclization and oxy-Michael cyclization approaches.
Cr-mediated coupling reactions are usually achieved with a slight excess of a given nucleophile. To develop a cost-effective use… 
Highly Cited
2009
Highly Cited
2009
Macromolecular interaction of halichondrin B analogues eribulin (E7389) and ER-076349 with tubulin by analytical ultracentrifugation.
Halichondrin B is an antimitotic drug that inhibits microtubule assembly. To understand the molecular details of its interaction… 
2009
2009
Second generation synthesis of C27-C35 building block of E7389, a synthetic halichondrin analogue.
A practical method is reported to synthesize E7389 C27-C35 building block 13 from 1,2-O-isopropylidene-alpha-D-5-deoxyglucurono-6… 
Highly Cited
2007
Highly Cited
2007
Antiproliferative effects of halichondrin B analog eribulin mesylate (E7389) against paclitaxel-resistant human cancer cells in vitro
C58 Eribulin (E7389, ER-086526, NSC-707389), a structurally-simplified synthetic analog of the biologically active macrocyclic… 
Highly Cited
2006
Highly Cited
2006
Comparison of the Activities of the Truncated Halichondrin B Analog NSC 707389 (E7389) with Those of the Parent Compound and a Proposed Binding Site on Tubulin
The complex marine natural product halichondrin B was compared with NSC 707389 (E7389), a structurally simplified, synthetic… 
Highly Cited
2005
Highly Cited
2005
A phase I pharmacokinetic and target validation study of the novel anti-tubulin agent E7389: A California Cancer Consortium trial
3036 Background: The California Cancer Consortium recently completed a Phase I pharmacokinetic (PK) and target validation (TV… 
Highly Cited
2004
Highly Cited
2004
Induction of Morphological and Biochemical Apoptosis following Prolonged Mitotic Blockage by Halichondrin B Macrocyclic Ketone Analog E7389
E7389, a macrocyclic ketone analog of the marine natural product halichondrin B, currently is undergoing clinical trials for… 
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