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eribulin mesylate

Known as: eribulin (as mesylate), eribulin mesilate, eribulin monomethanesulfonate 
The mesylate salt of a synthetic analogue of halichondrin B, a substance derived from a marine sponge (Lissodendoryx sp.) with antineoplastic… Expand
National Institutes of Health

Papers overview

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Highly Cited
2016
Highly Cited
2016
BACKGROUND A non-randomised, phase 2 study showed activity and tolerability of eribulin in advanced or metastatic soft-tissue… Expand
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Highly Cited
2015
Highly Cited
2015
Purpose This phase III randomized trial (ClinicalTrials.gov identifier: NCT00337103) compared eribulin with capecitabine in… Expand
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Highly Cited
2014
Highly Cited
2014
Background:Eribulin mesilate (eribulin), a non-taxane microtubule dynamics inhibitor, has shown trends towards greater overall… Expand
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Highly Cited
2014
Highly Cited
2014
Eribulin mesylate is a synthetic macrocyclic ketone analog of the marine sponge natural product halichondrin B and an inhibitor… Expand
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Highly Cited
2014
Highly Cited
2014
Data from two phase 3 studies of eribulin were pooled in analyses initially requested by the European Medicines Agency to assess… Expand
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Highly Cited
2011
Highly Cited
2011
BACKGROUND Treatments with survival benefit are greatly needed for women with heavily pretreated metastatic breast cancer… Expand
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Highly Cited
2011
Highly Cited
2011
BACKGROUND Eribulin inhibits microtubule dynamics via a mechanism distinct from that of other tubulin-targeting drugs, inducing… Expand
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Highly Cited
2011
Highly Cited
2011
Chemotherapy-induced neurotoxicity is a significant problem associated with successful treatment of many cancers. Tubulin is a… Expand
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Highly Cited
2010
Highly Cited
2010
Eribulin mesylate (E7389), a synthetic analogue of the marine natural product halichondrin B, is in phase III clinical trials for… Expand
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Highly Cited
2009
Highly Cited
2009
Purpose: To evaluate the maximum tolerated dose (MTD), dose-limiting toxicities (DLT), and pharmacokinetics of eribulin mesylate… Expand
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