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epostane

Known as: 4,5-epoxy-3,17-dihydroxy-4,17-dimethylandrost-2-ene-2-carbonitrile (4alpha,5alpha,17beta) 
National Institutes of Health

Related topics

Related topics

2 relations

Broader (2)

Abortifacient Agents, SteroidalAndrostenols

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2004
2004
Structure/function aspects of human 3β-hydroxysteroid dehydrogenase
Highly Cited
2001
Highly Cited
2001
Ventral Tegmental Area Infusions of Inhibitors of the Biosynthesis and Metabolism of 3α,5α‐THP Attenuate Lordosis of Hormone‐Primed and Behavioural Oestrous Rats and Hamsters
The importance of progesterone biosynthesis and metabolism to 5α‐pregnan‐3α‐ol‐20‐one (3α,5α‐THP), which exerts its effects via… 
2001
2001
Periovulatory changes in catfish ovarian oestradiol-17beta, oestrogen-2-hydroxylase and catechol-O-methyltransferase during GnRH analogue-induced ovulation and in vitro induction of oocyte maturation…
In the catfish Heteropneustes fossilis and Clarias batrachus, ovarian oestrogen-2-hydroxylase (OE-2-H) activity increased… 
1997
1997
Inhibition and augmentation of progesterone production during pregnancy: effects on parturition in rhesus monkeys.
Highly Cited
1991
Highly Cited
1991
Comparison of inhibitory actions of indomethacin and epostane on ovulation in rats.
Indomethacin, an inhibitor of cyclooxygenase that generates prostaglandins (PGs) from arachidonic acid, and 2 alpha,4 alpha,7-4,5… 
1990
1990
Inhibitory effect of synthetic progestins, 4-MA and cyanoketone on human placental 3β-hydroxysteroid dehydrogenase/5→4-ene-isomerase activity
1988
1988
Termination of early pregnancy by the 3 beta-hydroxysteroid dehydrogenase inhibitor epostane.
Progesterone is essential to sustain pregnancy in the first eight weeks. Its synthesis requires the enzyme 3 beta-hydroxysteroid… 
1985
1985
Interruption of first trimester human pregnancy following Epostane therapy. Effect of prostaglandin E2 pessaries
Summary. The effect of Epostane, a competitive inhibitor of the 3β hydroxy steroid dehydrogenase enzyme system in combination… 
1985
1985
A simple in vitro approach to the estimation of the biopotency of drugs affecting adrenal steroidogenesis.
1985
1985
Myometrial activity in first trimester human pregnancy after Epostane therapy. Effect of intravenous oxytocin
Summary. The effect on myometrial activity of Epostane, a competitive inhibitor of the 3β‐hydroxy steroid dehydrogenase enzyme… 
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