• Publications
  • Influence
Is dehydroepiandrosterone a hormone?
Dehydroepiandrosterone (DHEA) is not a hormone but it is a very important prohormone secreted in large amounts by the adrenals in humans and other primates, but not in lower species. It is secretedExpand
  • 418
  • 26
  • PDF
Endocrine and intracrine sources of androgens in women: inhibition of breast cancer and other roles of androgens and their precursor dehydroepiandrosterone.
Serum androgens as well as their precursors and metabolites decrease from the age of 30-40 yr in women, thus suggesting that a more physiological hormone replacement therapy at menopause shouldExpand
  • 492
  • 25
  • PDF
Androgen biosynthetic pathways in the human prostate.
It is well recognized that there are two androgens, namely testosterone (T) and dihydrotestosterone (DHT); T plays an important role in the testis and muscle, and DHT is crucial for the development,Expand
  • 174
  • 20
17beta-hydroxysteroid dehydrogenase (HSD)/17-ketosteroid reductase (KSR) family; nomenclature and main characteristics of the 17HSD/KSR enzymes.
A number of enzymes possessing 17beta-hydroxysteroid dehydrogenase/17-ketosteroid reductase (17HSD/KSR) activities have been described and cloned, but their nomenclature needs specification. ToExpand
  • 288
  • 16
  • PDF
Structure and Expression of a New Complementary DNA Encoding the almost Exclusive 3β-Hydroxysteroid Dehydrogenase/Δ5-Δ4-lsomerase in Human Adrenals and Gonads
The 3β-hydroxysteroid dehydrogenase/Δ5-Δ4 isomerase (3βHSD) enzyme catalyzes the oxidation and isomerization of Δ5−3β-hydroxysteroid precursors into Δ4-ketosteroids, thus leading to the formation ofExpand
  • 329
  • 12
Intracrinology: role of the family of 17 beta-hydroxysteroid dehydrogenases in human physiology and disease.
In women and men, an important proportion of estrogens and androgens are synthesized locally at their site of action in peripheral target tissues. This new field of endocrinology has been calledExpand
  • 289
  • 12
  • PDF
Characteristics of a Highly Labile Human Type 5 17β-Hydroxysteroid Dehydrogenase1.
17β-Hydroxysteroid dehydrogenases (17βHSDs) play an essential role in the formation of active intracellular sex steroids. Six types of 17βHSD have been described to date, which only shareExpand
  • 222
  • 12
Gonadotropin-releasing hormone agonists in the treatment of prostate cancer.
In 1979, the first prostate cancer patient was treated with a GnRH agonist at the Laval University Medical Center in Quebec City, Canada, thus rapidly leading to the worldwide replacement of surgicalExpand
  • 146
  • 11
DHEA and Peripheral Androgen and Estrogen Formation: Intracrinology
Despite the fact that the concentration of dehydroepiandrosterone sulfate (DHEAS) in the circulation of adult men and women is higher than that of any other steroid, except cholesterol, the biologicExpand
  • 260
  • 10
Neurosteroids: expression of steroidogenic enzymes and regulation of steroid biosynthesis in the central nervous system.
Steroid hormones, which are synthesized in the adrenal gland, gonads and placenta, exert a large array of biological effects on the nervous system. In particular, steroid hormones play an importantExpand
  • 353
  • 9
  • PDF