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elacytarabine

The lipophilic 5'-elaidic acid ester of the deoxycytidine analog cytosine arabinoside (cytarabine; Ara-C) with potential antineoplastic activity. As… 
National Institutes of Health

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CP-4055

Papers overview

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Highly Cited
2014
Highly Cited
2014
International randomized phase III study of elacytarabine versus investigator choice in patients with relapsed/refractory acute myeloid leukemia.
PURPOSE Most patients with acute myeloid leukemia (AML) eventually experience relapse. Relapsed/refractory AML has a dismal… 
Review
2014
Review
2014
Novel Developments in the Use of Antimetabolites
Antimetabolites are the most widely used and most efficacious group of anticancer drugs. Antimetabolites are also the oldest… 
2012
2012
Elacytarabine has single‐agent activity in patients 
with advanced acute myeloid leukaemia
Elacytarabine is a novel cytotoxic nucleoside analogue, independent of nucleoside transporters (e.g. human Equilibrative… 
2012
2012
A somatic EZH2 mutation in childhood acute myeloid leukemia
2012
2012
Phase I and pharmacokinetic study of elacytarabine, a novel 5′-elaidic acid derivative of cytarabine, in adults with refractory hematological malignancies
Phase I and pharmacokinetic study of elacytarabine, a novel 5′-elaidic acid derivative of cytarabine, in adults with refractory… 
2012
2012
Mechanisms and consequences of the loss of PHLPP1 phosphatase in chronic lymphocytic leukemia (CLL)
The PHLPP (pleckstrin homology domain and leucine-rich repeat protein phosphatase) family of novel Ser/Thr phosphatases serve as… 
Highly Cited
2011
Highly Cited
2011
Metabolism and accumulation of the lipophilic deoxynucleoside analogs elacytarabine and CP-4126
SummaryCytarabine (ara-C) and gemcitabine (dFdC) are commonly used anticancer drugs, which depend on the equilibrative (ENT) and… 
2010
2010
The Activity of the Lipophilic Nucleoside Derivatives Elacytarabine and CP-4126 in a Panel of Tumor Cell Lines Resistant to Nucleoside Analogues
The clinical activity of pyrimidine analogues (araC and gemcitabine) is impaired by different mechanisms of resistance and… 
2010
2010
Induction of Resistance to the Lipophilic Cytarabine Prodrug Elacytarabine (CP-4055) in CEM Leukemic Cells
The deoxynucleoside analogs cytarabine (Ara-C) and gemcitabine (dFdC) are widely used in the treatment of cancer. Due to their… 
Review
2010
Review
2010
Novel agents and regimens for acute myeloid leukemia: 2009 ASH annual meeting highlights
Prognostic markers, such as NPM1, Flt3-ITD, and cytogenetic abnormalities have made it possible to formulate aggressive treatment… 
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