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Tumour exosome integrins determine organotropic metastasis
Ever since Stephen Paget’s 1889 hypothesis, metastatic organotropism has remained one of cancer’s greatest mysteries. Here we demonstrate that exosomes from mouse and human lung-, liver- andExpand
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The gene expression profiles of primary and metastatic melanoma yields a transition point of tumor progression and metastasis
BackgroundThe process of malignant transformation, progression and metastasis of melanoma is poorly understood. Gene expression profiling of human cancer has allowed for a unique insight into theExpand
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Mechanism of chemoresistance mediated by miR-140 in human osteosarcoma and colon cancer cells
In this study, high-throughput microRNA (miRNA) expression analysis revealed that the expression of miR-140 was associated with chemosensitivity in osteosarcoma tumor xenografts. Tumor cellsExpand
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High levels of messenger RNAs for tissue inhibitors of metalloproteinases (TIMP-1 and TIMP-2) in primary breast carcinomas are associated with development of distant metastases.
Tissue inhibitors of metalloproteinases (TIMPs) are believed to possess several cellular functions, particularly the contrasting activities of inhibiting tissue-degrading enzymes and promotingExpand
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MicroRNA-125b Confers the Resistance of Breast Cancer Cells to Paclitaxel through Suppression of Pro-apoptotic Bcl-2 Antagonist Killer 1 (Bak1) Expression*
Paclitaxel (Taxol) is an effective chemotherapeutic agent for treatment of cancer patients. Despite impressive initial clinical responses, the majority of patients eventually develop some degree ofExpand
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Identification of novel epigenetically modified genes in human melanoma via promoter methylation gene profiling
The inactivation of tumor‐related genes through the aberrant methylation of promoter CpG islands is thought to contribute to tumor initiation and progression. We therefore investigated promoterExpand
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Photochemical internalization: a novel technology for delivery of macromolecules into cytosol.
The therapeutic usefulness of macromolecules, such as in gene therapy, is often limited by an inefficient transfer of the macromolecule to the cytosol and a lack of tissue-specific targeting. TheExpand
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The Stem Cell‐Associated Antigen CD133 (Prominin‐1) Is a Molecular Therapeutic Target for Metastatic Melanoma
CD133 (Prominin‐1) is considered the most important cancer stem cell (CSC)‐associated marker identified so far, with increased expression in the CSC fraction of a large variety of human malignancies,Expand
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Overcoming trastuzumab resistance in breast cancer by targeting dysregulated glucose metabolism.
Trastuzumab shows remarkable efficacy in treatment of ErbB2-positive breast cancers when used alone or in combination with other chemotherapeutics. However, acquired resistance develops in mostExpand
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Epigenetics in human melanoma.
BACKGROUND Recent technological advances have allowed us to examine the human genome in greater detail than ever before. This has opened the door to an improved understanding of the gene expressionExpand
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