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efflux pump complex

Known as: efflux transmembrane transporter complex location, efflux transmembrane transporter complex, efflux pump 
A protein complex that is capable of efflux transmembrane transporter activity. [GOC:dos, PMID:21556065, PMID:9417051]
National Institutes of Health

Papers overview

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2016
2016
Special Section on Pediatric Drug Disposition and Pharmacokinetics Proteomic Analysis of the Developmental Trajectory of Human Hepatic Membrane Transporter Proteins in the First Three Months of Life
Human hepatic membrane-embedded transporter proteins are involved in trafficking endogenous and exogenous substrates. Even though… 
2014
2014
Evaluation of Genetic Pattern and Determination of oqxA Gene Expression Levels among Clinical Isolates of Klebsiella Pneumoniae Strains
Background and purpose: The increasing emergence of multidrug resistance among Klebsiella pneumoniae nosocomial isolates has… 
2013
2013
Rationally Designed Transmembrane Peptide Mimics of the Multidrug Transporter Protein Cdr1 Act as Antagonists to Selectively Block Drug Efflux and Chemosensitize Azole-resistant Clinical Isolates of…
Background: Transmembrane peptide mimics (TMPMs) may be useful to prevent helix-helix interaction of multidrug transporter… 
2011
2011
Evaluation of forty new phenothiazine derivatives for activity against intrinsic efflux pump systems of reference Escherichia coli, Salmonella Enteritidis, Enterococcus faecalis and Staphylococcus…
BACKGROUND Because phenothiazines inhibit efflux pumps of bacteria, forty new phenothiazine derivatives were tested for their… 
2004
2004
Class III B-Tubulin Overexpression Is a Prominent Mechanism of Paclitaxel Resistance in Ovarian Cancer Patients
The vast majority of women with advanced ovarian cancer will ultimately relapse and develop a drug-resistant disease with an… 
2001
2001
In Vitro and in Vivo Reversal of P-Glycoprotein-mediated Multidrug Resistance by a Novel Potent Modulator , XR 9576
  • 2001
  • Corpus ID: 21453389
The overexpression of P-glycoprotein (P-gp) on the surface of tumor cells causes multidrug resistance (MDR). This protein acts as… 
1998
1998
P-Glycoprotein Expression on Normal and Abnormally Expanded Natural Killer Cells and Inhibition of P-Glycoprotein Function by Cyclosporin A and Its Analogue , PSC 833
P-glycoprotein (P-gp), a transmembrane efflux pump encoded by the MDR1 gene, has been found to be expressed in many normal bone… 
1996
1996
Experimental Models for the Study of Drug Resistance in Osteosarcoma: P-Glycoprotein-Positive, Murine Osteosarcoma Cell Lines*
P-glycoprotein is an adenosine triphosphate-dependent drug-efflux pump that extrudes drugs from cells and causes drug resistance… 
1991
1991
Does P-glycoprotein predict response to chemotherapy, and if so, is there a reliable way to detect it?
The development of resistance to cancer chemotherapeutic drugs remains a major obstacle in the treatment of cancer patients… 
1990
1990
Effect of exposure to calcium entry blockers on doxorubicin accumulation and cytotoxicity in multidrug-resistant cells.
Flow cytometry has been used to measure doxorubicin (DOX) retention in several pairs of drug-sensitive and multidrug-resistant… 
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