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efflux pump complex

Known as: efflux transmembrane transporter complex location, efflux transmembrane transporter complex, efflux pump 
A protein complex that is capable of efflux transmembrane transporter activity. [GOC:dos, PMID:21556065, PMID:9417051]
National Institutes of Health

Papers overview

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Highly Cited
2009
Highly Cited
2009
Resident microbiota of the gypsy moth midgut harbors antibiotic resistance determinants.
Little is known about the significance of insects as environmental reservoirs of antibiotic-resistant bacteria. We characterized… 
Highly Cited
2008
Highly Cited
2008
Nucleotide-induced Structural Changes in P-glycoprotein Observed by Electron Microscopy*
P-glycoprotein (Pgp) is an ATP hydrolysis driven multidrug efflux pump, which, when overexpressed in the plasma membrane of… 
Highly Cited
2001
Highly Cited
2001
MDR1-Mediated Drug Resistance inCandida dubliniensis
ABSTRACT Candida dubliniensis is a recently described opportunistic fungal pathogen that is closely related to Candida albicans… 
Highly Cited
2000
Highly Cited
2000
Bacteremic pneumonia due to multidrug-resistant pneumococci in 3 patients treated unsuccessfully with azithromycin and successfully with levofloxacin.
Three patients with bacteremic pneumonia caused by multidrug-resistant Streptococcus pneumoniae were treated unsuccessfully with… 
Highly Cited
1999
Highly Cited
1999
Both ATP sites of human P-glycoprotein are essential but not symmetric.
Human P-glycoprotein (P-gp) is a cell surface drug efflux pump that contains two nucleotide binding domains (NBDs). Mutations… 
Highly Cited
1996
Highly Cited
1996
Synthetic hydrophobic peptides are substrates for P-glycoprotein and stimulate drug transport.
P-Glycoprotein functions as an ATP-driven active efflux pump for many natural products and chemotherapeutic drugs. Hydrophobic… 
Highly Cited
1994
Highly Cited
1994
Clinical modulation of multidrug resistance in multiple myeloma: effect of cyclosporine on resistant tumor cells.
PURPOSE In multiple myeloma (MM) refractory to doxorubicin (DXR) and/or vincristine (VCR), myeloma cells frequently express the… 
Highly Cited
1993
Highly Cited
1993
Monoclonal antibody to an external epitope of the human mdr1 P-glycoprotein.
A membrane glycoprotein, termed P-glycoprotein, has been shown to be responsible for cross-resistance to a broad range of… 
Highly Cited
1990
Highly Cited
1990
Regulation of the multidrug resistance gene in regenerating rat liver.
The MDR1 gene encodes an Mr 170,000 energy-dependent drug efflux pump (P-glycoprotein) which transports hydrophobic agents such… 
Highly Cited
1989
Highly Cited
1989
Expression of a human multidrug resistance cDNA (MDR1) in the bone marrow of transgenic mice: resistance to daunomycin-induced leukopenia
The human multidrug resistance gene (MDR1) encodes a drug efflux pump glycoprotein (P-glycoprotein) responsible for resistance to… 
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