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efflux pump complex

Known as: efflux transmembrane transporter complex location, efflux transmembrane transporter complex, efflux pump 
A protein complex that is capable of efflux transmembrane transporter activity. [GOC:dos, PMID:21556065, PMID:9417051]
National Institutes of Health

Papers overview

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Review
2004
Review
2004
Pharmacologic circumvention of multidrug resistance
The ability of malignant cells to develop resistance to chemotherapeutic drugs is a major obstacle to the successful treatment of… 
Highly Cited
2003
Highly Cited
2003
Transition state P-glycoprotein binds drugs and modulators with unchanged affinity, suggesting a concerted transport mechanism.
The P-glycoprotein multidrug transporter is a plasma membrane efflux pump for hydrophobic natural products, drugs, and peptides… 
Highly Cited
2002
Highly Cited
2002
The multidrug efflux pump NorA is not required for salicylate-induced reduction in drug accumulation by Staphylococcus aureus.
Highly Cited
2000
Highly Cited
2000
Bacteremic pneumonia due to multidrug-resistant pneumococci in 3 patients treated unsuccessfully with azithromycin and successfully with levofloxacin.
Three patients with bacteremic pneumonia caused by multidrug-resistant Streptococcus pneumoniae were treated unsuccessfully with… 
Highly Cited
1996
Highly Cited
1996
Efficient Purification and Reconstitution of P-glycoprotein for Functional and Structural Studies*
Plasma membrane P-glycoprotein is known as an ATP-dependent drug efflux pump that confers multidrug resistance to tumor cells… 
Highly Cited
1994
Highly Cited
1994
Clinical modulation of multidrug resistance in multiple myeloma: effect of cyclosporine on resistant tumor cells.
PURPOSE In multiple myeloma (MM) refractory to doxorubicin (DXR) and/or vincristine (VCR), myeloma cells frequently express the… 
Highly Cited
1993
Highly Cited
1993
Monoclonal antibody to an external epitope of the human mdr1 P-glycoprotein.
A membrane glycoprotein, termed P-glycoprotein, has been shown to be responsible for cross-resistance to a broad range of… 
Highly Cited
1991
Highly Cited
1991
Laser scanning and confocal microscopy of daunorubicin, doxorubicin, and rhodamine 123 in multidrug-resistant cells.
Highly Cited
1990
Highly Cited
1990
Expression of the mdr3 gene in prolymphocytic leukemia: Association with cyclosporin‐a‐induced increase in drug accumulation
Typical multidrug resistance in human and animal cell lines is caused by overactivity of an unidirectional transmembrane drug… 
Highly Cited
1989
Highly Cited
1989
Reciprocal correlation between expression of P-glycoprotein and accumulation of rhodamine 123 in human tumors.
The aim of this investigation was to determine whether a correlation exists between expression of the multi-drug-resistance… 
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