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ectonucleoside triphosphate diphosphohydrolase 1

Known as: Vascular ATP Diphosphohydrolase, EC 3.6.1.5, CD39 
Ectonucleoside triphosphate diphosphohydrolase 1 (510 aa, ~58 kDa) is encoded by the human ENTPD1 gene. This protein is involved in the activation of… Expand
National Institutes of Health

Papers overview

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Highly Cited
2010
Highly Cited
2010
RATIONALE Pulmonary fibrosis is a devastating as yet untreatable disease. We previously investigated the endogenous mediators… Expand
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Highly Cited
2009
Highly Cited
2009
T-cell activation requires the influx of extracellular calcium, although mechanistic details regarding such activation are not… Expand
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Highly Cited
2007
Highly Cited
2007
BACKGROUND Extracellular adenosine, generated from extracellular nucleotides via ectonucleotidases, binds to specific receptors… Expand
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Highly Cited
2007
Highly Cited
2007
In the immune system, extracellular ATP functions as a "natural adjuvant" that exhibits multiple proinflammatory effects. It is… Expand
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Highly Cited
2005
Highly Cited
2005
Nucleoside triphosphate diphosphohydrolases 1, 2, 3 and 8 (NTPDases 1, 2, 3 and 8) are the dominant ectonucleotidases and thereby… Expand
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Highly Cited
2004
Highly Cited
2004
The release of IL-1β is a tightly controlled process that requires induced synthesis of the precursor pro-IL-1β and a second… Expand
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Highly Cited
2004
Highly Cited
2004
UNLABELLED ATP is rapidly released from osteoblasts in response to mechanical load. We examined the mechanisms involved in this… Expand
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Highly Cited
2000
Highly Cited
2000
Extracellular nucleotides are ubiquitous extracellular mediators that interact with and activate nucleotide type 2 (P2) receptors… Expand
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Highly Cited
1996
Highly Cited
1996
Vascular ATP diphosphohydrolase (ATPDase) is a plasma membrane-bound enzyme that hydrolyses extracellular ATP and ADP to AMP… Expand
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Highly Cited
1972
Highly Cited
1972
Summary: Methods have been developed for the preparation of suspensions of washed platelets from humans. Heparin is used in the… Expand
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