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ecadotril

Known as: acetorphan, (S)-isomer, sinorphan 
National Institutes of Health

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Broader (1)

racecadotril

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2014
Review
2014
Combined neprilysin and renin-angiotensin system inhibition for the treatment of heart failure.
Neprilysin is an enzyme that contributes to the breakdown of the biologically active natriuretic peptides and several other… Expand
  • table 1
1999
1999
A randomized trial of ecadotril versus placebo in patients with mild to moderate heart failure: the U.S. ecadotril pilot safety study.
OBJECTIVE To determine the short-term safety and tolerability of the addition of ecadotril to conventional therapy in patients… Expand
Highly Cited
1998
Highly Cited
1998
Effects of neutral endopeptidase inhibition and combined angiotensin converting enzyme and neutral endopeptidase inhibition on angiotensin and bradykinin peptides in rats.
The combination of neutral endopeptidase 24.11 (NEP) and angiotensin converting enzyme (ACE) inhibition is a candidate therapy… Expand
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Highly Cited
1995
Highly Cited
1995
Neutral endopeptidase versus angiotensin converting enzyme inhibition in essential hypertension
Objective: To evaluate the antihypertensive efficacy of sinorphan, an orally active inhibitor of neutral endopeptidase EC 3.4.24… Expand
1993
1993
Inhibition of neutral endopeptidase stimulates renal sodium excretion in patients with chronic renal failure.
1. The acute effects of a single oral dose of sinorphan (100 mg), an inhibitor of neutral endopeptidase, on the plasma atrial… Expand
1991
1991
Effect of sinorphan, an enkephalinase inhibitor, on plasma atrial natriuretic factor and sodium urinary excretion in cirrhotic patients with ascites.
We examined the acute effects of sinorphan, an inhibitor of enkephalinase, on plasma atrial natriuretic factor (ANF) and urinary… Expand
Highly Cited
1990
Highly Cited
1990
Effect of sinorphan on plasma atrial natriuretic factor in congestive heart failure
1990
1990
Antihypertensive activity of sinorphan
1990
1990
Stereoselective protection of exogenous and endogenous atrial natriuretic factor by enkephalinase inhibitors in mice and humans.
We compared the relative potencies of sinorphan and retorphan, the S- and R-enantiomers of acetorphan a potent inhibitor of… Expand
1990
1990
Degradation of atrial natriuretic factor in mouse blood in vitro and in vivo: Role of enkephalinase (EC 3.4.24.11)
The half-life of 125I-ANF (99-126) in mouse blood in vivo, evaluated after HPLC analysis, was approximately 0.5 min. This value… Expand
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