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Itokawa Dust Particles: A Direct Link Between S-Type Asteroids and Ordinary Chondrites
Laboratory analysis of samples returned from an asteroid establishes a direct link between asteroids and meteorites and provides clues to the complex history of the asteroid and its surface. The… Expand
Rhythmic messenger ribonucleic acid expression of clock genes and adipocytokines in mouse visceral adipose tissue.
Various peripheral tissues show circadian rhythmicity, which is generated at the cellular level by their own core oscillators that are composed of transcriptional/translational feedback loops… Expand
Claudin-2–deficient mice are defective in the leaky and cation-selective paracellular permeability properties of renal proximal tubules
- S. Muto, M. Hata, +10 authors M. Furuse
- Chemistry, Medicine
- Proceedings of the National Academy of Sciences
- 12 April 2010
Claudin-2 is highly expressed in tight junctions of mouse renal proximal tubules, which possess a leaky epithelium whose unique permeability properties underlie their high rate of NaCl reabsorption.… Expand
Daily Rhythms of P‐glycoprotein Expression in Mice
- H. Ando, H. Yanagihara, +5 authors A. Fujimura
- Medicine, Biology
- Chronobiology international
- 1 January 2005
Recent studies have shown the gene expression of several transporters to be circadian rhythmic. However, it remains to be elucidated whether the expression of P‐glycoprotein, which is involved in the… Expand
Different effects of St John's Wort on the pharmacokinetics of simvastatin and pravastatin
- K. Sugimoto, M. Ohmori, +8 authors A. Fujimura
- Clinical pharmacology and therapeutics
- 1 December 2001
St John's Wort, a widely used herbal product, is an inducer of CYP3A4 and it decreases blood concentrations of CYP3A4 substrates. The effects of St John's Wort on the pharmacokinetics of… Expand
Clock gene expression in peripheral leucocytes of patients with type 2 diabetes
Aim/hypothesisRecent studies have demonstrated relationships between circadian clock function and the development of metabolic diseases such as type 2 diabetes. We investigated whether the peripheral… Expand
Impairment of peripheral circadian clocks precedes metabolic abnormalities in ob/ob mice.
Recent studies have demonstrated relationships between the dysfunction of circadian clocks and the development of metabolic abnormalities, but the chicken-and-egg question remains unresolved. To… Expand
TRPV4 as a flow sensor in flow-dependent K+ secretion from the cortical collecting duct.
- J. Taniguchi, S. Tsuruoka, A. Mizuno, J. Sato, A. Fujimura, M. Suzuki
- Medicine, Chemistry
- American journal of physiology. Renal physiology
- 1 February 2007
The transient receptor vanilloid-4 (TRPV4) is a mechanosensitive, swell-activated cation channel that is abundant in the renal distal tubules. Immunolocalization studies, however, present conflicting… Expand
Irradiation History of Itokawa Regolith Material Deduced from Noble Gases in the Hayabusa Samples
Laboratory analysis of samples returned from an asteroid establishes a direct link between asteroids and meteorites and provides clues to the complex history of the asteroid and its surface. Noble… Expand
Pravastatin prevents arrhythmias induced by coronary artery ischemia/reperfusion in anesthetized normocholesterolemic rats.
- J. Chen, Yoshinobu Nagasawa, +4 authors K. Hashimoto
- Medicine, Biology
- Journal of pharmacological sciences
HMG-CoA reductase inhibitors (statins) have been shown to decrease cardiovascular mortality. Since ventricular tachyarrhythmias are closely related to cardiovascular mortality, we tested effects of… Expand