• Publications
  • Influence
Itokawa Dust Particles: A Direct Link Between S-Type Asteroids and Ordinary Chondrites
Laboratory analysis of samples returned from an asteroid establishes a direct link between asteroids and meteorites and provides clues to the complex history of the asteroid and its surface. TheExpand
  • 346
  • 19
Rhythmic messenger ribonucleic acid expression of clock genes and adipocytokines in mouse visceral adipose tissue.
Various peripheral tissues show circadian rhythmicity, which is generated at the cellular level by their own core oscillators that are composed of transcriptional/translational feedback loopsExpand
  • 274
  • 16
Claudin-2–deficient mice are defective in the leaky and cation-selective paracellular permeability properties of renal proximal tubules
  • S. Muto, M. Hata, +10 authors M. Furuse
  • Chemistry, Medicine
  • Proceedings of the National Academy of Sciences
  • 12 April 2010
Claudin-2 is highly expressed in tight junctions of mouse renal proximal tubules, which possess a leaky epithelium whose unique permeability properties underlie their high rate of NaCl reabsorption.Expand
  • 210
  • 12
Daily Rhythms of P‐glycoprotein Expression in Mice
Recent studies have shown the gene expression of several transporters to be circadian rhythmic. However, it remains to be elucidated whether the expression of P‐glycoprotein, which is involved in theExpand
  • 63
  • 8
Different effects of St John's Wort on the pharmacokinetics of simvastatin and pravastatin
St John's Wort, a widely used herbal product, is an inducer of CYP3A4 and it decreases blood concentrations of CYP3A4 substrates. The effects of St John's Wort on the pharmacokinetics ofExpand
  • 219
  • 6
Clock gene expression in peripheral leucocytes of patients with type 2 diabetes
Aim/hypothesisRecent studies have demonstrated relationships between circadian clock function and the development of metabolic diseases such as type 2 diabetes. We investigated whether the peripheralExpand
  • 92
  • 6
  • PDF
Impairment of peripheral circadian clocks precedes metabolic abnormalities in ob/ob mice.
Recent studies have demonstrated relationships between the dysfunction of circadian clocks and the development of metabolic abnormalities, but the chicken-and-egg question remains unresolved. ToExpand
  • 100
  • 5
TRPV4 as a flow sensor in flow-dependent K+ secretion from the cortical collecting duct.
The transient receptor vanilloid-4 (TRPV4) is a mechanosensitive, swell-activated cation channel that is abundant in the renal distal tubules. Immunolocalization studies, however, present conflictingExpand
  • 83
  • 5
Irradiation History of Itokawa Regolith Material Deduced from Noble Gases in the Hayabusa Samples
Laboratory analysis of samples returned from an asteroid establishes a direct link between asteroids and meteorites and provides clues to the complex history of the asteroid and its surface. NobleExpand
  • 99
  • 5
Pravastatin prevents arrhythmias induced by coronary artery ischemia/reperfusion in anesthetized normocholesterolemic rats.
HMG-CoA reductase inhibitors (statins) have been shown to decrease cardiovascular mortality. Since ventricular tachyarrhythmias are closely related to cardiovascular mortality, we tested effects ofExpand
  • 49
  • 4
  • PDF