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let-7 MicroRNA transfer in pancreatic cancer-derived cells inhibits in vitro cell proliferation but fails to alter tumor progression.
This study describes here for the first time the extensive loss of expression of let-7 in PDAC, and provides the initial steps for a microRNA replacement therapy for this cancer. Expand
Antagonism in the human mineralocorticoid receptor
A new mechanism of antagonism is proposed in which the AF2‐AD core region is destabilized by the loss of contacts between the antagonist and the helix H12 region, proposed in the light of the hMR homology model. Expand
MicroRNA-21 is induced early in pancreatic ductal adenocarcinoma precursor lesions.
The findings indicate that miR-21 warrants further investigation as a marker for early detection of PDAC, and Aberrant microRNA production is an early event in the development of PanIN. Expand
The mineralocorticoid receptor discriminates aldosterone from glucocorticoids independently of the 11 beta-hydroxysteroid dehydrogenase.
To investigate the mechanisms involved in the in vivo aldosterone selectivity of the mineralocorticoid receptor (MR), we studied the respective contribution of the receptor and the enzyme 11Expand
Mixed inhibitors of angiotensin-converting enzyme (EC and enkephalinase (EC rational design, properties, and potential cardiovascular applications of glycopril and alatriopril.
Mixed inhibitors of the two peptidases show promise for the treatment of various cardiovascular and salt-retention disorders. Expand
Gene expression signature of advanced pancreatic ductal adenocarcinoma using low density array on endoscopic ultrasound-guided fine needle aspiration samples.
It is demonstrated that molecular studies on EUS-guided FNA material are feasible for the identification and quantification of markers in PDAC patients diagnosed with non-resectable tumours. Expand
Protection of atrial natriuretic factor against degradation: diuretic and natriuretic responses after in vivo inhibition of enkephalinase (EC by acetorphan.
Results indicate that enkephalinase plays a critical role in ANF degradation in vivo and that its inhibition enhances the levels of circulating endogenous ANF, which, in turn, results in diuresis and natriuresis. Expand
Specific hydroxylations determine selective corticosteroid recognition by human glucocorticoid and mineralocorticoid receptors
The ability of corticosteroids to stimulate the receptor's transactivation function is depending on the stability of the steroid‐receptor complexes, and it is proposed that contacts through the C21 hydroxyl group are sufficient to stabilize hMR but not hGR. Expand
Endoscopic ultrasound-guided fine-needle aspiration biopsy coupled with KRAS mutation assay to distinguish pancreatic cancer from pseudotumoral chronic pancreatitis.
The value of KRAS analysis in addition to EUS-FNAB is limited for distinguishing pancreatic mass lesions, but when chronic pancreatitis presented as a pseudotumor a negative finding (wild-type KRAS), was useful in strongly suggesting a benign lesion. Expand
Stereoselective protection of exogenous and endogenous atrial natriuretic factor by enkephalinase inhibitors in mice and humans.
Oral administered sinorphan appears to be a promising compound for therapeutic use in cardiovascular and renal diseases in which ANF has been postulated to exert beneficial effects. Expand