drug metabolism

Known as: biotransformation drugs, metabolism drug, drug metabolic process 
A series of chemical modifications of a drug compound by enzymatic activity that make the substrate (drug) more water soluble to allow its clearance… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1951-2018
020040019512017

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2014
Highly Cited
2014
DrugBank (http://www.drugbank.ca) is a comprehensive online database containing extensive biochemical and pharmacological… (More)
  • table 1
  • figure 1
Is this relevant?
Highly Cited
2009
Highly Cited
2009
We provide a demonstration in humans of the principle of pharmacometabonomics by showing a clear connection between an individual… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
Is this relevant?
Highly Cited
2008
Highly Cited
2008
DrugBank is a richly annotated resource that combines detailed drug data with comprehensive drug target and drug action… (More)
  • table 1
  • figure 1
Is this relevant?
Highly Cited
2006
Highly Cited
2006
DrugBank is a unique bioinformatics/cheminformatics resource that combines detailed drug (i.e. chemical) data with comprehensive… (More)
  • table 1
  • figure 1
Is this relevant?
Highly Cited
2006
Highly Cited
2006
BACKGROUND AND OBJECTIVE Many drugs, including proton pump inhibitors and certain antidepressants, are metabolized by the… (More)
Is this relevant?
Highly Cited
2001
Highly Cited
2001
Cytochrome P450 3A4 is an important mediator of drug catabolism that can be regulated by the steroid and xenobiotic receptor (SXR… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
2000
Highly Cited
2000
St. John's wort (Hypericum perforatum) is an herbal remedy used widely for the treatment of depression. Recent clinical studies… (More)
  • figure 2
  • figure 1
  • figure 3
Is this relevant?
Highly Cited
2000
Highly Cited
2000
We used cDNA microarrays to explore the variation in expression of approximately 8,000 unique genes among the 60 cell lines used… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
1994
Highly Cited
1994
Interindividual variations in the level and activity of cytochrome P-450 enzymes were investigated in the liver microsomes of 30… (More)
Is this relevant?
Highly Cited
1975
Highly Cited
1975
A physiological approach has been developed recognizing that hepatic blood flow, the activity of the overall elimination process… (More)
Is this relevant?