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drug metabolism

Known as: biotransformation drugs, metabolism drug, drug metabolic process 
A series of chemical modifications of a drug compound by enzymatic activity that make the substrate (drug) more water soluble to allow its clearance… Expand
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2019
Review
2019
The microbiome plays a key role in health and disease, and there has been considerable interest in therapeutic targeting of the… Expand
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Review
2017
Review
2017
Despite the considerable number of available systems that recognize automatically mentions of genes/proteins and chemicals in… Expand
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Highly Cited
2014
Highly Cited
2014
DrugBank (http://www.drugbank.ca) is a comprehensive online database containing extensive biochemical and pharmacological… Expand
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Highly Cited
2009
Highly Cited
2009
We provide a demonstration in humans of the principle of pharmacometabonomics by showing a clear connection between an individual… Expand
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Highly Cited
2008
Highly Cited
2008
DrugBank is a richly annotated resource that combines detailed drug data with comprehensive drug target and drug action… Expand
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Review
2005
Review
2005
Differences in drug responsiveness are common, often leading to challenges in optimizing the dosage regimen for a particular… Expand
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Review
2005
Review
2005
Drug metabolizing enzymes (DMEs) play central roles in the metabolism, elimination and detoxification of xenobiotics and drugs… Expand
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Review
1999
Review
1999
Cytochrome P-450 (P-450) 3A4 is the most abundant P-450 expressed in human liver and small intestine. P-450 3A4 contributes to… Expand
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Highly Cited
1994
Highly Cited
1994
Interindividual variations in the level and activity of cytochrome P-450 enzymes were investigated in the liver microsomes of 30… Expand
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Highly Cited
1973
Highly Cited
1973
A number of recent reports indicate that massive overdoses of acetaminophen can produce a fulminant hepatic necrosis in man… Expand
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