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drug metabolism

Known as: biotransformation drugs, metabolism drug, drug metabolic process 
A series of chemical modifications of a drug compound by enzymatic activity that make the substrate (drug) more water soluble to allow its clearance… 
National Institutes of Health

Related topics

Related topics

47 relations
AromataseCOMT geneCYP19A1 geneCYP19A1 protein, human

Broader (2)

Drug Kineticsdrug clearance

Narrower (3)

alcohol metabolismdrug eliminationphase II biotransformation

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2005
Review
2005
Prediction of drug metabolism and interactions on the basis of in vitro investigations.
Drug metabolism profoundly affects drug action, because almost all drugs are metabolised in the body and thus their… 
Review
2001
Review
2001
Effects of cruciferous vegetables and their constituents on drug metabolizing enzymes involved in the bioactivation of DNA-reactive dietary carcinogens.
Highly Cited
1996
Highly Cited
1996
Multiple forms of human P450 expressed in Saccharomyces cerevisiae. Systematic characterization and comparison with those of the rat.
Highly Cited
1995
Highly Cited
1995
Capillary electrophoresis-mass spectrometry
Review
1985
Review
1985
Free drug measurements: methodology and clinical significance.
  • T. Kwong
  • Clinica chimica acta; international journal of…
  • 1985
  • Corpus ID: 45957688
Highly Cited
1979
Highly Cited
1979
Stimulatory effect of brussels sprouts and cabbage on human drug metabolism
Ten healthy volunteers were fed (1) a control diet for 10 days, (2) the same control diet for 3 additional days and a brussels… 
Highly Cited
1978
Highly Cited
1978
Renal necrosis, glutathione depletion, and covalent binding after acetaminophen.
Highly Cited
1972
Highly Cited
1972
Mechanism of cholestasis. 5. Bile acids in normal rat livers and in those after bile duct ligation.
Highly Cited
1964
Highly Cited
1964
FURTHER STUDIES ON THE INHIBITION AND STIMULATION OF MICROSOMAL DRUG METABOLIZING ENZYMES OF RAT LIVER BY VARIOUS COMPOUNDS.
Highly Cited
1955
Highly Cited
1955
Enzymatic dealkylation of aminopyrine (pyramidon) and other alkylamines.
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