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drug metabolism

Known as: biotransformation drugs, metabolism drug, drug metabolic process 
A series of chemical modifications of a drug compound by enzymatic activity that make the substrate (drug) more water soluble to allow its clearance… 
National Institutes of Health

Related topics

Related topics

47 relations
AromataseCOMT geneCYP19A1 geneCYP19A1 protein, human

Broader (2)

Drug Kineticsdrug clearance

Narrower (3)

alcohol metabolismdrug eliminationphase II biotransformation

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
1985
Review
1985
The use of microorganisms for the study of drug metabolism
The potential for the use of microorganisms as tools in the study of drug metabolism appears to be unlimited. The selected… 
Highly Cited
1982
Highly Cited
1982
Comparative effects of dietary administration of 2(3)-tert-butyl-4-hydroxyanisole and 3,5-di-tert-butyl-4-hydroxytoluene on several hepatic enzyme activities in mice and rats.
Effects of feeding mice and rats with 2(3)-tert-butyl-4-hydroxyanisole (BHA) and 3,5-di-tert-butyl-4-hydroxytoluene (BHT), the… 
Highly Cited
1982
Highly Cited
1982
Homogeneous interferon from E. coli depresses hepatic cytochrome P-450 and drug biotransformation.
Highly Cited
1980
Highly Cited
1980
Concepts in drug metabolism
Make more knowledge even in less time every day. You may not always spend your time and money to go abroad and get the experience… 
Highly Cited
1978
Highly Cited
1978
Formation and metabolism of a glutathione-S-conjugate in isolated rat liver and kidney cells.
Highly Cited
1977
Highly Cited
1977
The effect of dimethylsulfoxide and other hydroxyl radical scavengers on the oxidation of ethanol by rat liver microsomes.
Highly Cited
1972
Highly Cited
1972
Inhibition of hepatic oxidative xenobiotic metabolism by piperonyl butoxide.
Review
1971
Review
1971
Enhancement and inhibition of drug metabolism.
A large number of factors can alter rates of drug metabolism. This re­ view wiII discuss the enhancement and inhibition of drug… 
Highly Cited
1968
Highly Cited
1968
Inhibition of drug metabolism. V. Inhibition of drug metabolism by steroids.
In a study employing hepatic microsomes from rats, estradiol-17β, testosterone, androsterone, progesterone, and hydrocortisone… 
Highly Cited
1964
Highly Cited
1964
FURTHER STUDIES ON THE INHIBITION AND STIMULATION OF MICROSOMAL DRUG METABOLIZING ENZYMES OF RAT LIVER BY VARIOUS COMPOUNDS.
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