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drug metabolism

Known as: biotransformation drugs, metabolism drug, drug metabolic process 
A series of chemical modifications of a drug compound by enzymatic activity that make the substrate (drug) more water soluble to allow its clearance… Expand
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2014
Highly Cited
2014
DrugBank (http://www.drugbank.ca) is a comprehensive online database containing extensive biochemical and pharmacological… Expand
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Review
2013
Review
2013
Cytochromes P450 (CYP) are a major source of variability in drug pharmacokinetics and response. Of 57 putatively functional human… Expand
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Highly Cited
2008
Highly Cited
2008
DrugBank is a richly annotated resource that combines detailed drug data with comprehensive drug target and drug action… Expand
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Review
2006
Review
2006
Animal models are commonly used in the preclinical development of new drugs to predict the metabolic behaviour of new compounds… Expand
Review
2005
Review
2005
  • G. Wilkinson
  • The New England journal of medicine
  • 2005
  • Corpus ID: 21857991
Differences in drug responsiveness are common, often leading to challenges in optimizing the dosage regimen for a particular… Expand
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Review
2005
Review
2005
Drug metabolizing enzymes (DMEs) play central roles in the metabolism, elimination and detoxification of xenobiotics and drugs… Expand
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Review
1999
Review
1999
  • F. Guengerich
  • Annual review of pharmacology and toxicology
  • 1999
  • Corpus ID: 36331311
Cytochrome P-450 (P-450) 3A4 is the most abundant P-450 expressed in human liver and small intestine. P-450 3A4 contributes to… Expand
Highly Cited
1994
Highly Cited
1994
Interindividual variations in the level and activity of cytochrome P-450 enzymes were investigated in the liver microsomes of 30… Expand
Review
1992
Review
1992
The cytochromes P450 are a superfamily of hemoproteins that catalyze the metabolism of a large number of xenobiotics and… Expand
Highly Cited
1973
Highly Cited
1973
A number of recent reports indicate that massive overdoses of acetaminophen can produce a fulminant hepatic necrosis in man… Expand