FAQ

discoidin domain receptor 2

Known as: Neurotrophic Tyrosine Kinase, Receptor-Related 3 Protein, DDR2 Protein, DDR2 Kinase 
A discoidin domain receptor for FIBRILLAR COLLAGEN and non-fibrillar COLLAGEN TYPE X. It functions in many cellular and developmental processes that… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

2000-2018
051020002018

Related topics

Related topics

10 relations
DDR1 protein, humanIn Bloodadministration & dosageagonists
(More)

Narrower (1)

Discoidin Domain-Containing Receptor 2, Human

Broader (1)

Receptor Protein-Tyrosine Kinases

Related mentions per year

Related mentions per year

1936-2018
19401960198020002020
discoidin domain receptor 2
physiological aspects
agonists
Receptor Protein-Tyrosine Kinases
Discoidin Domain-Containing Receptor 2, Human
DDR1 protein, human

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2013
Highly Cited
2013
The collagen receptor discoidin domain receptor 2 stabilizes SNAIL1 to facilitate breast cancer metastasis
Increased stromal collagen deposition in human breast tumours correlates with metastases. We show that activation of the collagen… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
2013
2013
Discoidin domain receptor 2 regulates neutrophil chemotaxis in 3D collagen matrices.
Neutrophils express a variety of collagen receptors at their surface, yet their functional significance remains unclear. Although… (More)
Is this relevant?
2013
2013
Phosphoproteomic analysis identifies insulin enhancement of discoidin domain receptor 2 phosphorylation
The discoidin domain receptors (DDRs) are a unique class of receptor tyrosine kinases (RTKs) that bind to and are activated by… (More)
  • figure 1
Is this relevant?
2010
2010
Attenuation of osteoarthritis progression by reduction of discoidin domain receptor 2 in mice.
OBJECTIVE To investigate whether the reduction of discoidin domain receptor 2 (DDR-2), a cell membrane tyrosine kinase receptor… (More)
Is this relevant?
2008
2008
Upregulation of discoidin domain receptor 2 in nasopharyngeal carcinoma.
BACKGROUND Nasopharyngeal carcinoma (NPC) is associated with Epstein-Barr virus (EBV) and has high metastatic potential… (More)
Is this relevant?
2007
2007
Structural basis of the collagen-binding mode of discoidin domain receptor 2.
Discoidin domain receptor (DDR) is a cell-surface receptor tyrosine kinase activated by the binding of its discoidin (DS) domain… (More)
  • figure 1
  • table I
  • figure 2
  • table II
  • figure 4
Is this relevant?
2005
2005
Expression of Discoidin Domain Receptor 2 (DDR2) in the developing heart.
Interactions between cells and the surrounding extracellular matrix are important for a number of developmental events. In the… (More)
Is this relevant?
2005
2005
Discoidin domain receptor 2 mediates tumor cell cycle arrest induced by fibrillar collagen.
During malignant invasion tumor cells establish contact with extracellular matrix proteins, including fibrillar collagen. In… (More)
Is this relevant?
Highly Cited
2005
Highly Cited
2005
Human hepatic stellate cell lines, LX-1 and LX-2: new tools for analysis of hepatic fibrosis.
BACKGROUND Hepatic stellate cells (HSCs) are a major fibrogenic cell type that contributes to collagen accumulation during… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
2005
Highly Cited
2005
Activation of the discoidin domain receptor 2 induces expression of matrix metalloproteinase 13 associated with osteoarthritis in mice.
Human genetic studies indicate that mutations in type IX and XI collagens result in early-onset osteoarthritis (OA) with a wide… (More)
Is this relevant?