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Discoidin domain receptor 2 is associated with the increased expression of matrix metalloproteinase-13 in synovial fibroblasts of rheumatoid arthritis

• Jin Su, Jiangtian Yu, +7 authors Li-bo Yao
• Molecular and Cellular Biochemistry
• 2009

Regulation of matrix metalloproteinase-13 (MMP-13) by collagen matrix in the synovial fibroblasts of rheumatoid arthritis (RA) is critical event in the progressive joint destruction. Our previous… (More)

An essential role of discoidin domain receptor 2 (DDR2) in osteoblast differentiation and chondrocyte maturation via modulation of Runx2 activation.

• Yan Zhang, Jin Su, +4 authors Li-bo Yao
• Journal of bone and mineral research : the…
• 2011

Discoidin domain receptor 2 (DDR2) belongs to receptor tyrosine kinase (RTK) family and is activated by collagen binding. Although the bone defects in Ddr2 null mice have been reported for a decade,… (More)

Spiroplasma citri Surface Protein P89 Implicated in Adhesion to Cells of the Vector Circulifer tenellus.

• Jiangtian Yu, Astri C. Wayadande, Jonathan Fletcher
• Phytopathology
• 2000

ABSTRACT Two microtiter plate assays were developed to study the adherence of the plant-pathogenic mollicute Spiroplasma citri to a monolayer of cultured cells of its leafhopper vector, Circulifer… (More)

A host deficiency of discoidin domain receptor 2 (DDR2) inhibits both tumour angiogenesis and metastasis.

• Shuya Zhang, Xin Bu, +9 authors Jin Su
• The Journal of pathology
• 2014

Discoidin domain receptor 2 (DDR2) is a unique receptor tyrosine kinase (RTK) that signals in response to collagen binding and is implicated in tumour malignant phenotypes such as invasion and… (More)

Targeting of Discoidin Domain Receptor 2 (DDR2) Prevents Myofibroblast Activation and Neovessel Formation During Pulmonary Fibrosis.

• Hu Zhao, Huan Bian, +8 authors Jin Su
• Molecular therapy : the journal of the American…
• 2016

Idiopathic pulmonary fibrosis (IPF) is a lethal human disease with short survival time and few treatment options. Herein, we demonstrated that discoidin domain receptor 2 (DDR2), a receptor tyrosine… (More)

Ubiquitin ligase Cbl-b acts as a negative regulator in discoidin domain receptor 2 signaling via modulation of its stability.

• Jiangtian Yu, Hu Zhao, +4 authors Jin Su
• FEBS letters
• 2014

Discoidin domain receptor 2 (DDR2), a collagen receptor tyrosine kinase, initiates signal transduction upon collagen binding, but little is known as to how DDR2 signaling is negatively regulated.… (More)

Fusion expression of DDR2 extracellular domain in insect cells and its purification and function characterization.

• Wei Zhang, Tianbing Ding, +9 authors Li-bo Yao
• Journal of cellular biochemistry
• 2007

Discoidin domain receptor 2 (DDR2) is a kind of protein tyrosine kinases associated with cell proliferation and tumor metastasis, and collagen, a ligand for DDR2, up-regulates matrix… (More)

[The attachment manner of ubiquitin to proinflammatory molecule discoidin domain receptor 2].

• Jiangtian Yu, Xin Bu, Hu Zhao, Xia Li, Jin Su
• Xi bao yu fen zi mian yi xue za zhi = Chinese…
• 2015

OBJECTIVE To understand which lysine (K) residue in ubiquitin (Ub) is used to form a poly-Ubs chain on discoidin domain receptor 2 (DDR2). METHODS The constructs encoding human DDR2 and Cbl-b were… (More)

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