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- Publications
- Influence
Characterization of SIS3, a Novel Specific Inhibitor of Smad3, and Its Effect on Transforming Growth Factor-β1-Induced Extracellular Matrix Expression
This is the first report that characterizes specific inhibitor of Smad3 (SIS3) as a potent and selective inhibitor of Smad3 function. In the reporter assay, the increased luciferase activity of… Expand
Impaired IL-17 Signaling Pathway Contributes to the Increased Collagen Expression in Scleroderma Fibroblasts
- T. Nakashima, M. Jinnin, +9 authors H. Ihn
- Biology, Medicine
- The Journal of Immunology
- 15 April 2012
Among IL-17 families, IL-17A and IL-17F share amino acid sequence similarity and bind to IL-17R type A. IL-17 signaling is implicated in the pathogenesis of various autoimmune diseases, but its role… Expand
Tenascin-C upregulation by transforming growth factor-β in human dermal fibroblasts involves Smad3, Sp1, and Ets1
- M. Jinnin, H. Ihn, Y. Asano, K. Yamane, M. Trojanowska, K. Tamaki
- Biology, Medicine
- Oncogene
- 4 March 2004
In cultured human dermal fibroblasts, transforming growth factor (TGF)-β induced the mRNA expression of tenascin-C (TN-C). The molecular mechanism(s) underlying this process is not presently… Expand
The circulating microRNA-221 level in patients with malignant melanoma as a new tumor marker.
- H. Kanemaru, S. Fukushima, +8 authors H. Ihn
- Medicine
- Journal of dermatological science
- 1 March 2011
BACKGROUND
MicroRNA-221 (miR-221) is known to be abnormally expressed in malignant melanoma (MM) cells, and it favors the induction of the malignant phenotype through down-modulation of… Expand
Increased Expression of Integrin αvβ5 Induces the Myofibroblastic Differentiation of Dermal Fibroblasts
- Yoshihide Asano, H. Ihn, K. Yamane, M. Jinnin, K. Tamaki
- Biology
- 1 February 2006
The biological effect of cytokines is mainly determined by the cytokine-receptor interaction, which is modulated by the concentration and the activity of cytokines and/or their receptors. Because… Expand
Characterization of monocyte/macrophage subsets in the skin and peripheral blood derived from patients with systemic sclerosis
- Nobuyo Higashi-Kuwata, M. Jinnin, +8 authors H. Ihn
- Biology, Medicine
- Arthritis research & therapy
- 5 July 2010
IntroductionRecent accumulating evidence indicates a crucial involvement of macrophage lineage in the pathogenesis of systemic sclerosis (SSc). To analyze the assembly of the monocyte/macrophage… Expand
The Downregulation of microRNA let-7a Contributes to the Excessive Expression of Type I Collagen in Systemic and Localized Scleroderma
Systemic and localized scleroderma (SSc and LSc) is characterized by excessive deposition of collagen and tissue fibrosis in the skin. Although they have fundamental common characteristics including… Expand
Clinical and laboratory features of scleroderma patients developing skeletal myopathy
- Y. Mimura, H. Ihn, M. Jinnin, Y. Asano, K. Yamane, K. Tamaki
- Medicine
- Clinical Rheumatology
- 1 April 2005
Skeletal muscle involvement, or myopathy, has been a recognized feature of systemic sclerosis (SSc). We studied retrospectively 302 Japanese patients with SSc to elucidate the clinical and laboratory… Expand
Down-Regulation of mir-424 Contributes to the Abnormal Angiogenesis via MEK1 and Cyclin E1 in Senile Hemangioma: Its Implications to Therapy
- T. Nakashima, M. Jinnin, +6 authors H. Ihn
- Biology, Medicine
- PloS one
- 14 December 2010
Background Senile hemangioma, so-called cherry angioma, is known as the most common vascular anomalies specifically seen in the aged skin. The pathogenesis of its abnormal angiogenesis is still… Expand
Kinesin-2 controls development and patterning of the vertebrate skeleton by Hedgehog- and Gli3-dependent mechanisms.
- E. Kolpakova-Hart, M. Jinnin, B. Hou, N. Fukai, B. Olsen
- Biology, Medicine
- Developmental biology
- 15 September 2007
Hedgehog signaling plays an essential role in patterning of the vertebrate skeleton. Here we demonstrate that conditional inactivation of the Kif3a subunit of the kinesin-2 intraflagellar transport… Expand