directed evolution

 
National Institutes of Health

Papers overview

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Highly Cited
2013
Highly Cited
2013
Inherited retinal degenerative diseases are a clinically promising focus of adeno-associated virus (AAV)-mediated gene therapy… (More)
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Review
2011
Review
2011
Directed evolution is widely used to improve enzymes, particularly for industrial biocatalytic processes. Molecular biology… (More)
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Highly Cited
2011
Highly Cited
2011
The de novo design of protein-protein interfaces is a stringent test of our understanding of the principles underlying protein… (More)
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Highly Cited
2006
Highly Cited
2006
The efficiency and high specificity of tobacco etch virus (TEV) protease has made it widely used for cleavage of recombinant… (More)
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Highly Cited
2006
Highly Cited
2006
The arsenal of engineered variants of the GFP [green FP (fluorescent protein)] from Aequorea jellyfish provides researchers with… (More)
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Review
2005
Review
2005
Many research groups successfully rely on whole-gene random mutagenesis and recombination approaches for the directed evolution… (More)
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2005
2005
The engineering of enzymes with altered activity, specificity and stability, using directed evolution techniques that mimic… (More)
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Review
2001
Review
2001
The efficient application of biocatalysts requires the availability of suitable enzymes with high activity and stability under… (More)
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Highly Cited
2001
Highly Cited
2001
Directed evolution can be a powerful tool to predict antibiotic resistance. Resistance involves the accumulation of mutations… (More)
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Highly Cited
2000
Highly Cited
2000
Using directed evolution, we have improved the hydantoinase process for production of L-methionine (L-met) in Escherichia coli… (More)
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