directed evolution
National Institutes of Health
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Advances in genome engineering are attendant on the development of novel enzyme variants with programed substrate specificities…
The formate dehydrogenase (FDH) from Candida boidinii is a well‐known enzyme in biocatalysis for NADH regeneration. Nevertheless…
Synthetic organophosphates (OPs) have been used as nerve agents and pesticides due to their extreme toxicity and have caused…
Triosephosphate isomerase from Saccharomyces cerevisiae (wt-TIM) is an obligated homodimer. The interface of wt-TIM is formed by…
There have been many approaches to solving problems associated with protein solubility. This article describes the application of…
We have engineered human epidermal growth factor (EGF) by directed evolution through yeast surface display for significantly…
G protein-coupled receptors (GPCRs) form a class of biological chemical sensors with an enormous diversity in ligand binding and…
Thermotoga neapolitana 1,4-β-d-glucan glucohydrolase A preferentially hydrolyzes cello-oligomers, such as cellotetraose…
The Escherichia coli aspartate (AATase) and tyrosine (TATase) aminotransferases share 43% sequence identity and 72% similarity…