directed evolution
National Institutes of Health
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Natural biocomposites are shaped by proteins that have evolved to interact with inorganic materials. Protein directed evolution…
Most protocols for the high-throughput directed evolution of enzymes rely on random encapsulation to link phenotype and genotype…
Directed evolution is a powerful strategy for gene mutagenesis, and has been used for protein engineering both in scientific…
Malolactic fermentation (MLF) is an important step in winemaking, which can be notoriously unreliable due to the fastidious…
The CTLA4-Ig therapeutics abatacept and belatacept inhibit CD28-mediated T cell activation by binding CD80 (B7-1) and CD86 (B7-2…
Arginine deiminase (ADI) is an important arginine-degrading enzyme with wide applications, in particular as an anti-cancer agent…
In order to improve the efficiency of directed evolution experiments, in silico multiple‐substrate clustering was combined with…
Cytochrome P450s (CYPs, P450s) comprise the superfamily of heme-containing oxidoreductase enzymes found in various organisms…
Directed evolution of transcription factors can be employed to effectively improve the phenotypes which are controlled by…
The enzyme transketolase (Enzyme Commission number: 2.2.1.1) has significant potential as a biocatalyst in the production of…