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Cooperativity in oxidations catalyzed by cytochrome P450 3A4.
TLDR
A model is presented in which binding of substrate in a particular conformation can facilitate oxygen activation to enhance catalysis and support a model in which an allosteric site is involved, although the proximity of this putative site to the catalytic site cannot be ascertained as of yet. Expand
Resveratrol is a selective human cytochrome P450 1A1 inhibitor.
TLDR
The results suggest that resveratrol is a selective human P450 1A1 inhibitor, and may be considered for use as a strong cancer chemopreventive agent in humans. Expand
Mechanism-based inhibition of human cytochrome P450 1A1 by rhapontigenin.
TLDR
The results suggest that rhapontigenin is a potent mechanism-based inactivator of human P450 1A1 and may be considered as a good candidate for a cancer chemopreventive agent in humans. Expand
Cytochrome P450 1B1: a target for inhibition in anticarcinogenesis strategies.
TLDR
2,4,3',5'-tetramethoxystilbene is a selective inhibitor of P450 1B1 relative to other P450s, and may be useful in preventing cancer caused by estrogens and xenobiotics. Expand
A new selective and potent inhibitor of human cytochrome P450 1B1 and its application to antimutagenesis.
TLDR
TMS is selective for inhibiting P450 1B1 among other human P450s including 1A1, 1A2, and 3A4 and warrants consideration as a candidate for preventing mammary tumor formation by E(2) in humans. Expand
Purification of functional recombinant P450s from bacteria.
TLDR
This chapter discusses the methods for the purification of functional recombinant P450s from bacteria, and focuses on recombinant human P 450s expressed in Escherichia coli and, Salmonella typhimurium. Expand
Design, synthesis, and discovery of novel trans-stilbene analogues as potent and selective human cytochrome P450 1B1 inhibitors.
TLDR
It is found that a substituent at the 2-position of the stilbene skeleton plays a very important role in discriminating between CYP1As and CYP3,5-dimethoxyphenyl moiety. Expand
Bacterial Lipopolysaccharides Induce Steroid Sulfatase Expression and Cell Migration through IL-6 Pathway in Human Prostate Cancer Cells
TLDR
It is suggested that LPS induces STS expression through IL-6 pathway in human prostate cancer cells through PI3K/Akt-dependent pathways. Expand
Abundance of aryl hydrocarbon receptor potentiates benzo[a]pyrene-induced apoptosis in Hepa1c1c7 cells via CYP1A1 activation.
TLDR
It is suggested that the abundance of endogenous AhR level is an indispensable condition for an efficient cellular signaling of B[a]P and that control of AhR activity in Hepa1c1c7 cells might be important to cell fate resulting from CYP1A1 activation after B[ a]P. Expand
In vitro evaluation of biomarkers for cisplatin-induced nephrotoxicity using HK-2 human kidney epithelial cells.
TLDR
KIM-1, calbindin and TIMP-1 can be effectively used as in vitro biomarkers for cisplatin-induced nephrotoxicity using a HK-2 human kidney cell system, and in vivo validation of the in vitro results is provided. Expand
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