dimethyl fumarate

Known as: Dimethyl (E)-Butenedioate, 2-butenedioic acid, (2E)-, dimethyl ester, Dimethylfumarate 
An orally bioavailable methyl ester of fumaric acid and activator of nuclear factor erythroid 2 [NF-E2]-related factor 2 (Nrf2, Nfe2l2), with… (More)
National Institutes of Health

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15 relations

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BG 00012BG 12 compoundFAG 201Fumaderm
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Broader (3)

Dermatologic AgentsImmunosuppressive AgentsRadiation-Sensitizing Agents
In Bloodagonistsanalogs & derivativesantagonists & inhibitors
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Papers overview

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Highly Cited
2015
Highly Cited
2015
PML in a patient with lymphocytopenia treated with dimethyl fumarate.
n engl j med 372;15 nejm.org april 9, 2015 1476 MP. PML in a patient treated with dimethyl fumarate from a compounding pharmacy… (More)
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Highly Cited
2014
Highly Cited
2014
Hydroxycarboxylic acid receptor 2 mediates dimethyl fumarate's protective effect in EAE.
Taken orally, the drug dimethyl fumarate (DMF) has been shown to improve functional outcomes for patients with MS; however, it is… (More)
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Highly Cited
2013
Highly Cited
2013
PML in a patient treated with dimethyl fumarate from a compounding pharmacy.
n engl j med 368;17 nejm.org april 25, 2013 1658 plementary Appendix). Methylprednisolone was administered at a dose of 500 mg… (More)
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Highly Cited
2012
Highly Cited
2012
Placebo-controlled phase 3 study of oral BG-12 for relapsing multiple sclerosis.
BACKGROUND BG-12 (dimethyl fumarate) was shown to have antiinflammatory and cytoprotective properties in preclinical experiments… (More)
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Highly Cited
2012
Highly Cited
2012
Fumarates promote cytoprotection of central nervous system cells against oxidative stress via the nuclear factor (erythroid-derived 2)-like 2 pathway.
Oxidative stress is central to the pathology of several neurodegenerative diseases, including multiple sclerosis, and… (More)
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Highly Cited
2012
Highly Cited
2012
Fumarate Is Cardioprotective via Activation of the Nrf2 Antioxidant Pathway
The citric acid cycle (CAC) metabolite fumarate has been proposed to be cardioprotective; however, its mechanisms of action… (More)
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Highly Cited
2006
Highly Cited
2006
JHDM2A, a JmjC-Containing H3K9 Demethylase, Facilitates Transcription Activation by Androgen Receptor
Covalent modification of histones plays an important role in regulating chromatin dynamics and transcription. Histone methylation… (More)
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Highly Cited
2001
Highly Cited
2001
Formation of high-quality CdTe, CdSe, and CdS nanocrystals using CdO as precursor.
High-quality colloidal semiconductor nanocrystals are nanometer-sized, single crystalline fragments of the corresponding bulk… (More)
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Review
1999
Review
1999
Marine viruses and their biogeochemical and ecological effects
Viruses are the most common biological agents in the sea, typically numbering ten billion per litre. They probably infect all… (More)
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Highly Cited
1971
Highly Cited
1971
Hemoglobin synthesis in murine virus-induced leukemic cells in vitro: stimulation of erythroid differentiation by dimethyl sulfoxide.
Cells of a cloned line of murine virus-induced erythroleukemia were stimulated to differentiate along the erythroid pathway by… (More)
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