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difenoxin

Known as: Diphenoxylic acid, Difenoxina, Diphenoxilic acid 
A phenylpiperidine with antidiarrheal activity and an active metabolite of diphenoxylate. Difenoxin is chemically related to the narcotic opioid… 
National Institutes of Health

Related topics

Related topics

10 relations
AntidiarrhealsDiarrheaDrug AllergyEnterocolitis, Pseudomembranous

Narrower (1)

Difenoxin hydrochloride

Broader (1)

Diphenoxylate

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
Spatial Memory, Motor Coordination, Cerebellar and Hippocampal Histoarchitectural Changes following Atropine Administration to Adult Mice
Atropine is a non-selective muscarinic receptor antagonist. In overdoses, atropine is poisonous. It is sometimes added to… 
1993
1993
Difenoxin and loperamide: studies on possible mechanisms of intestinal antisecretory action
SummaryExperiments have been performed to determine whether the antisecretory (antidiarrhoeal) actions of difenoxin and… 
1993
1993
Do antidiarrhoeal opiates accumulate in the rat intestinal lumen?
Abstract— The opiate antidiarrhoeal drugs loperamide (0·6 mg kg−1, i.p.) or difenoxin (0·77 mg kg−1, s.c), were administered in… 
1992
1992
Determination of methadone and its metabolites by high performance liquid chromatography following solid-phase extraction in rat plasma.
This paper describes a rapid, quantitative liquid chromatographic analysis and extraction of methadone and its two major… 
1980
1980
Universal reagent immunosorbent assay (URI) for haptens.
1978
1978
[Diphenoxin hydrochloride a new antidiarrhoic agent].
1976
1976
The measurement of diphenoxylic acid in plasma following administration of diphenoxylate.
The measurement of diphenoxylic acid, the major metabolite of diphenoxylate, has been performed in man using a deuterium labelled… 
1976
1976
The effect of difenoxin on the lower esophageal sphincter pressure in man.
Difenoxin, a new antidiarrheal agent, had no effect on lower esophageal sphincter pressure in man when given at an oral dose of 2… 
1976
1976
[On the mode of action of difenoxin (R 15 403). Part 2: Studies on the perfused isolated colonic loop of the rat (author's transl)].
The effect of 1-(3-cyano-3,3-diphenylpropyl)-4-phenyl-isonipecotinic acid hydrochloride (difenoxin, R 15 403), a new… 
1972
1972
Pharmacokinetics and metabolism of diphenoxylate in man
The absorption, excretion, and biotransformation of 14C‐diphenoxylate hydrochloride (5 mg. containing 20.2 µc of 14C) when… 
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