Drug, Meal and Formulation Interactions Influencing Drug Absorption After Oral Administration
- D. Fleisher, Cheng Li, Yuji Zhou, L. Pao, A. Karim
- Biology, MedicineClinical Pharmacokinetics
- 1 March 1999
The current status of information regarding interactions which may influence the gastrointestinal (GI) absorption of orally administered drugs is presented and regional differences in membrane permeability are discussed.
Pharmacokinetics of celecoxib after oral administration in dogs and humans: effect of food and site of absorption.
- S. Paulson, M. Vaughn, A. Karim
- Medicine, BiologyJournal of Pharmacology and Experimental…
- 1 May 2001
It is suggested that celecoxib is a highly permeable drug that can be absorbed throughout the GI tract and that dissolution may be a rate-limiting factor for absorption from solid dosage forms and that patients with arthritis can be given Celecoxib with or without food.
Pharmacokinetic, pharmacodynamic, and tolerability profiles of the dipeptidyl peptidase-4 inhibitor alogliptin: a randomized, double-blind, placebo-controlled, multiple-dose study in adult patients…
- P. Covington, R. Christopher, A. Karim
- MedicineClinical Therapeutics
- 1 March 2008
Disposition Kinetics and Tolerance of Escalating Single Doses of Ramelteon, a High‐Affinity MT1 and MT2 Melatonin Receptor Agonist Indicated for Treatment of Insomnia
- A. Karim, D. Tolbert, C. Cao
- MedicineJournal of clinical pharmacology
- 1 February 2006
Safety, tolerance, pharmacokinetics, and cognitive performance were evaluated following increasing ramelteon doses andabolite M‐II, which has shown weak ramelTeon‐like activity in vitro, was the major metabolite in serum.
Pharmacokinetics, pharmacodynamics, and tolerability of single increasing doses of the dipeptidyl peptidase-4 inhibitor alogliptin in healthy male subjects.
- R. Christopher, P. Covington, A. Karim
- MedicineClinical Therapeutics
- 1 March 2008
Disposition of a specific cyclooxygenase-2 inhibitor, valdecoxib, in human.
- Josh J Yuan, Dai-Chang Yang, Ji Y. Zhang, R. Bible, A. Karim, J. Findlay
- Medicine, ChemistryDrug Metabolism And Disposition
- 1 September 2002
Absorption of valDecoxib was excellent since the recovery of unchanged valdecoxib in feces was <1% of the administered dose, suggesting that renal clearance is insignificant for valdec oxib.
Age and Gender Effects on the Pharmacokinetics and Pharmacodynamics of Ramelteon, a Hypnotic Agent Acting via Melatonin Receptors MT1 and MT2
- David J. Greenblatt, Jerold S. Harmatz, A. Karim
- Medicine, BiologyJournal of clinical pharmacology
- 1 April 2007
The reduced clearance and higher serum levels of ramelteon in elderly subjects were not associated with enhanced pharmacodynamic effects, and the usually recommended clinical dose of ramElteon (8 mg) does not require modification based on age or gender.
Effects of Celecoxib, a Novel Cyclooxygenase‐2 Inhibitor, on Platelet Function in Healthy Adults: A Randomized, Controlled Trial
- P. Leese, R. Hubbard, A. Karim, P. Isakson, Shawn S. Yu, G. Geis
- Medicine, BiologyJournal of clinical pharmacology
- 1 February 2000
The results indicate that even at supratherapeutic doses, celecoxib will not interfere with normal mechanisms of platelet aggregation and hemostasis, supporting the premise that cele Coxib is COX‐1 sparing relative to conventional NSAIDs.
Metabolism and Excretion of [14C]Celecoxib in Healthy Male Volunteers
- S. Paulson, J. Hribar, A. Karim
- Medicine, Chemistry
- 1 March 2000
The disposition of a single 300-mg dose of [14C]celecoxib in eight healthy male subjects was determined and celecoxib was well absorbed, reaching peak plasma concentrations within 2 h of dosing.
Pharmacokinetics of alogliptin when administered with food, metformin, or cimetidine: a two-phase, crossover study in healthy subjects.
- A. Karim, P. Covington, Q. Mekki
- Medicine, BiologyInternational journal of clinical pharmacology…
- 2010
Alogliptin can be administered without regard to meals and with metformin or cimetidine without the need for dose adjustment and tolerability was similar under all conditions.
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