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Drug, Meal and Formulation Interactions Influencing Drug Absorption After Oral Administration
The current status of information regarding interactions which may influence the gastrointestinal (GI) absorption of orally administered drugs is presented and regional differences in membrane permeability are discussed. Expand
Pharmacokinetic, pharmacodynamic, and tolerability profiles of the dipeptidyl peptidase-4 inhibitor alogliptin: a randomized, double-blind, placebo-controlled, multiple-dose study in adult patients…
This study evaluated the pharmacokinetic (PK), pharmacodynamic (PD), and tolerability profiles and explore the efficacy of multiple oral doses of alogliptin in patients with T2D to find out whether these doses can be combined to treat type 2 diabetes. Expand
Pharmacokinetics of celecoxib after oral administration in dogs and humans: effect of food and site of absorption.
- S. Paulson, M. Vaughn, +6 authors A. Karim
- The Journal of pharmacology and experimental…
- 1 May 2001
It is suggested that celecoxib is a highly permeable drug that can be absorbed throughout the GI tract and that dissolution may be a rate-limiting factor for absorption from solid dosage forms and that patients with arthritis can be given Celecoxib with or without food. Expand
Disposition Kinetics and Tolerance of Escalating Single Doses of Ramelteon, a High‐Affinity MT1 and MT2 Melatonin Receptor Agonist Indicated for Treatment of Insomnia
Safety, tolerance, pharmacokinetics, and cognitive performance were evaluated following increasing ramelteon doses andabolite M‐II, which has shown weak ramelTeon‐like activity in vitro, was the major metabolite in serum. Expand
Pharmacokinetics, pharmacodynamics, and tolerability of single increasing doses of the dipeptidyl peptidase-4 inhibitor alogliptin in healthy male subjects.
Alogliptin at single doses up to 800 mg inhibited plasma DPP-4 activity, increased active GLP-1, and was generally well tolerated, with no dose-limiting toxicity in healthy male subjects. Expand
Age and Gender Effects on the Pharmacokinetics and Pharmacodynamics of Ramelteon, a Hypnotic Agent Acting via Melatonin Receptors MT1 and MT2
The reduced clearance and higher serum levels of ramelteon in elderly subjects were not associated with enhanced pharmacodynamic effects, and the usually recommended clinical dose of ramElteon (8 mg) does not require modification based on age or gender. Expand
Metabolism and Excretion of [14C]Celecoxib in Healthy Male Volunteers
We determined the disposition of a single 300-mg dose of [14C]celecoxib in eight healthy male subjects. The [14C]celecoxib was administered as a fine suspension reconstituted in 80 ml of an apple… Expand
Plasma protein binding of celecoxib in mice, rat, rabbit, dog and human
- S. Paulson, T. A. Kaprak, +5 authors A. Karim
- Biology, Medicine
- Biopharmaceutics & drug disposition
- 1 September 1999
The plasma protein binding of celecoxib was determined for animals and humans using in vitro and ex vivo methods and the percent binding of celebcoxib to plasma proteins in vitro was slightly lower than those values determined ex vivo. Expand
Disposition of a specific cyclooxygenase-2 inhibitor, valdecoxib, in human.
- Josh J Yuan, Dai-Chang Yang, Ji Y Zhang, R. Bible, A. Karim, J. W. Findlay
- Chemistry, Medicine
- Drug metabolism and disposition: the biological…
- 1 September 2002
Absorption of valDecoxib was excellent since the recovery of unchanged valdecoxib in feces was <1% of the administered dose, suggesting that renal clearance is insignificant for valdec oxib. Expand
Pharmacokinetics of alogliptin when administered with food, metformin, or cimetidine: a two-phase, crossover study in healthy subjects.
- A. Karim, P. Covington, +5 authors Q. Mekki
- International journal of clinical pharmacology…
Alogliptin can be administered without regard to meals and with metformin or cimetidine without the need for dose adjustment and tolerability was similar under all conditions. Expand