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Diphenoxylate

Known as: 2,2-Diphenyl-4-(4-carbethoxy-4-phenylpiperidino)butyronitrile, 4-Piperidinecarboxylic acid, 1-(3-cyano-3,3-diphenylpropyl)-4-phenyl-, ethyl ester, Difenoxilato 
A piperidine derivate, chemically related to narcotic meperidine with antidiarrheal activity and devoid of central nervous system (CNS) activity… 
National Institutes of Health

Related topics

Related topics

23 relations

Broader (2)

Analgesics, OpioidAntidiarrheals
Atropine / DiphenoxylateAtropine Sulfate 0.025 MG / Diphenoxylate Hydrochloride 2.5 MG Oral Tablet [Lomotil]DehydrationDiarrhea

Narrower (5)

LomotilLonoxLyspafendifenoximide

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
Bioactive Constituents , Metabolites , and Functions Bacterial cellulose relieves diphenoxylate-induced constipation in rats
  • 2018
  • Corpus ID: 206608110
is published by the American Chemical Society. 1155 Sixteenth Street N.W., Washington, DC 20036 Published by American Chemical… 
2012
2012
Antidiarrheal activity of Pterocarpus erinaceus methanol leaf extract in experimentally-induced diarrhea.
Highly Cited
2005
Highly Cited
2005
Gastrointestinal manifestations of Fabry disease: clinical response to enzyme replacement therapy.
1993
1993
Bowel rest, intravenous hydration, and continuous high‐dose infusion of octreotide acetate for the treatment of chemotherapy‐induced diarrhea in patients with colorectal carcinoma
Background. A prospective trial was conducted involving 16 patients with colorectal adenocarcinoma using a regimen of continuous… 
Review
1991
Review
1991
Diphenoxylate-atropine (Lomotil) overdose in children: an update (report of eight cases and review of the literature)
Eight pediatric accidental overdoses of diphenoxylate-atropine (Lomotil) are reported, and 28 literature cases are reviewed. This… 
1990
1990
Serum-soluble interleukin-2 receptor levels in Kawasaki disease.
1986
1986
Failure of lactose-restricted diets to prevent radiation-induced diarrhea in patients undergoing whole pelvis irradiation.
1985
1985
Nonfluid therapy and selected chemoprophylaxis of acute diarrhea.
Highly Cited
1976
Highly Cited
1976
3,3-Diphenyl-3-(2-alkyl-1,3,4-oxadiazol-5-yl)propylcycloalkylamines, a novel series of antidiarrheal agents.
A series of 4-amino-2,2-diarylbutyronitriles (3) prepared for testing as inhibitors of gastrointestinal propulsive activity did… 
1972
1972
Immunological Studies on Heroin Addiction.
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