Antidiarrheals

Known as: Agents, Antidiarrheal, Antidiarrheal, Antidiarrhea Agents 
Miscellaneous agents found useful in the symptomatic treatment of diarrhea. They have no effect on the agent(s) that cause diarrhea, but merely… (More)
National Institutes of Health

Related topics

Related topics

43 relations

Narrower (30)

1 ML Octreotide 0.1 MG/ML Injection4-bromophenacyl bromideBI SUBSALICYLATE 459MG/MG AL SILICATE/SAL AC/NA SALICYLATE/30MLBIFIDOBACTERIUM/LACTOBACILLUS/STREPTOCOCCUS CAP,ORAL
(More)
Antiperistaltic AgentsDemulcentDiarrheaDifenoxin hydrochloride
(More)

Broader (1)

Gastrointestinal Agents

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2010
2010
Crofelemer, an antisecretory antidiarrheal proanthocyanidin oligomer extracted from Croton lechleri, targets two distinct intestinal chloride channels.
Crofelemer, a purified proanthocyanidin oligomer extracted from the bark latex of Croton lechleri, is in clinical trials for… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Review
2006
Review
2006
CFTR chloride channel drug discovery--inhibitors as antidiarrheals and activators for therapy of cystic fibrosis.
The Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) is a cAMP-activated chloride channel expressed in epithelia in the… (More)
Is this relevant?
Highly Cited
2004
Highly Cited
2004
Discovery of Glycine Hydrazide Pore-occluding CFTR Inhibitors
The cystic fibrosis transmembrane conductance regulator (CFTR) protein is a cAMP-regulated epithelial Cl- channel that, when… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
2002
Highly Cited
2002
Intensity-modulated whole pelvic radiotherapy in women with gynecologic malignancies.
PURPOSE To describe our initial clinical experience with intensity-modulated whole pelvic radiotherapy (IM-WPRT) in women with… (More)
Is this relevant?
2001
2001
Polyamine analogue antidiarrheals: a structure-activity study.
The syntheses of a group of spermine polyamine analogues and their evaluation as antidiarrheals are described. Each compound was… (More)
Is this relevant?
Highly Cited
2000
Highly Cited
2000
Increased drug delivery to the brain by P-glycoprotein inhibition.
BACKGROUND Although the antidiarrheal loperamide is a potent opiate, it does not produce opioid central nervous system effects at… (More)
Is this relevant?
Highly Cited
1998
Highly Cited
1998
Phase I trial of continuous infusion flavopiridol, a novel cyclin-dependent kinase inhibitor, in patients with refractory neoplasms.
PURPOSE We conducted a phase I trial of the cyclin-dependent kinase inhibitor, flavopiridol (National Service Center [NSC] 649890… (More)
Is this relevant?
Highly Cited
1996
Highly Cited
1996
P-glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugs.
The mouse mdr1a (also called mdr3) P-GP is abundant in the blood-brain barrier, and its absence in mdr1a (-/-) mice leads to… (More)
  • figure 1
  • figure 2
  • table II
  • table I
  • table III
Is this relevant?
1985
1985
Nigerian geophagical clay: a traditional antidiarrheal pharmaceutical.
The chief geophagical clay entering the West African market system comes from the village of Uzalla, Nigeria. Village inhabitants… (More)
Is this relevant?
1984
1984
Loperamide: blockade of calcium channels as a mechanism for antidiarrheal effects.
The antidiarrheal opiates loperamide, fluperamide, diphenoxylate and fetoxylate inhibited binding of [3H]nitrendipine to… (More)
Is this relevant?