didemnin B

Known as: L-Tyrosine, N-[1-[N-[4-[[3-Hydroxy-4-[[N-[N-[1-(2-hydroxy-1-oxopropyl)- L-prolyl]-N-methyl-L-leucyl]-L-threonyl]amino]-5-methyl-1-oxoheptyl]oxy]-2,5-dimethyl-1,3-dioxohexyl]-L-leucyl]- L-prolyl]-N,O-dimethyl-, phi-lactone (9CI), L-Tyrosine, N-[1-[N-[4-[[3-Hydroxy-4-[[N-[N-[1-(2-hydroxy-1-oxopropyl)- L-prolyl]-N-methyl-L-leucyl]-L-threonyl]amino-5-methyl-1-oxoheptyl]oxy]-2,5-dimethyl-1,3-dioxohexyl]-L-leucyl]- L-prolyl]-N,O-dimethyl-, .phi.-lactone (9CI), Didemnin 
A cyclic depsipeptide extracted from the Caribbean tunicate Trididemnum cyanophorum. Didemnin B activates caspase, thereby inducing apoptosis, and… (More)
National Institutes of Health

Papers overview

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Highly Cited
2015
Highly Cited
2015
  • Jun Ye
  • Artificial Intelligence in Medicine
  • 2015
OBJECTIVE In pattern recognition and medical diagnosis, similarity measure is an important mathematical tool. To overcome some… (More)
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2012
2012
The anti-neoplastic agent didemnin B from the Caribbean tunicate Trididemnum solidum was the first marine drug to be clinically… (More)
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2011
2011
Natural products obtained from marine invertebrates such as sponges and tunicates are attractive sources of drugs. However, a… (More)
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Highly Cited
2007
Highly Cited
2007
This article presents a new tracking technique for sine-BOC(n,n) (or Manchester encoded) ranging signals, which is most likely to… (More)
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2004
2004
Tris(2-carboxyethyl)phosphine (TCEP) is a widely used substitute for dithiothreitol (DTT) in the reduction of disulfide bonds in… (More)
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Review
2000
Review
2000
Of the six marine-derived compounds that have reached clinical trials as antitumor agents three-didemnin B, Aplidine, and… (More)
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1996
1996
Bioactivities of 42 didemnin congeners, either isolated from the marine tunicates Trididemnun solidum and Aplidium albicans or… (More)
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1995
1995
The cytotoxic and immunosuppressive marine depsipeptide didemnin B is a potent inhibitor of protein biosynthesis in intact cells… (More)
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Review
1986
Review
1986
A new class of marine compounds, the didemnins, with potent antitumor activity has been identified. They share the novel… (More)
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1984
1984
With the brush border membrane vesicles prepared from the rat kidney cortex, didemnin B and its parent compound, didemnin A… (More)
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