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didemnin B

Known as: L-Tyrosine, N-[1-[N-[4-[[3-Hydroxy-4-[[N-[N-[1-(2-hydroxy-1-oxopropyl)- L-prolyl]-N-methyl-L-leucyl]-L-threonyl]amino]-5-methyl-1-oxoheptyl]oxy]-2,5-dimethyl-1,3-dioxohexyl]-L-leucyl]- L-prolyl]-N,O-dimethyl-, phi-lactone (9CI), L-Tyrosine, N-[1-[N-[4-[[3-Hydroxy-4-[[N-[N-[1-(2-hydroxy-1-oxopropyl)- L-prolyl]-N-methyl-L-leucyl]-L-threonyl]amino-5-methyl-1-oxoheptyl]oxy]-2,5-dimethyl-1,3-dioxohexyl]-L-leucyl]- L-prolyl]-N,O-dimethyl-, .phi.-lactone (9CI), Didemnin 
A cyclic depsipeptide extracted from the Caribbean tunicate Trididemnum cyanophorum. Didemnin B activates caspase, thereby inducing apoptosis, and… Expand
National Institutes of Health

Papers overview

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Highly Cited
2015
Highly Cited
2015
  • J. Ye
  • Artif. Intell. Medicine
  • 2015
  • Corpus ID: 12383690
OBJECTIVE In pattern recognition and medical diagnosis, similarity measure is an important mathematical tool. To overcome some… Expand
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Highly Cited
2011
Highly Cited
2011
Natural products obtained from marine invertebrates such as sponges and tunicates are attractive sources of drugs. However, a… Expand
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Highly Cited
2010
Highly Cited
2010
A number of natural products from marine sponges, such as cyclodepsipeptides, have been identified. The structural… Expand
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Highly Cited
2006
Highly Cited
2006
Molecular dynamics (MD) simulations have been performed on N-methyl-N-propylpyrrolidinium bis(trifluoromethanesulfonyl)imide… Expand
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Highly Cited
2004
Highly Cited
2004
Tris(2-carboxyethyl)phosphine (TCEP) is a widely used substitute for dithiothreitol (DTT) in the reduction of disulfide bonds in… Expand
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Review
2000
Review
2000
  • K. Rinehart
  • Medicinal research reviews
  • 2000
  • Corpus ID: 25117225
Of the six marine-derived compounds that have reached clinical trials as antitumor agents three-didemnin B, Aplidine, and… Expand
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Highly Cited
1995
Highly Cited
1995
Description of reflection moveout from dipping interfaces is important in developing seismic processing methods for anisotropic… Expand
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Highly Cited
1994
Highly Cited
1994
The marine natural product, didemnin B, is a 7-amino acid, cyclic depsipeptide that inhibits G1 cell cycle progression at… Expand
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1989
1989
A series of glycolamide, glycolate, (acyloxy)methyl, alkyl, and aryl esters of acetylsalicylic acid (aspirin) were synthesized… Expand
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Highly Cited
1981
Highly Cited
1981
Extracts of samples of a Caribbean tunicate (ascidian, sea squirt) of the family Didemnidae inhibit in vitro at low… Expand
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