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didemnin B

Known as: L-Tyrosine, N-[1-[N-[4-[[3-Hydroxy-4-[[N-[N-[1-(2-hydroxy-1-oxopropyl)- L-prolyl]-N-methyl-L-leucyl]-L-threonyl]amino]-5-methyl-1-oxoheptyl]oxy]-2,5-dimethyl-1,3-dioxohexyl]-L-leucyl]- L-prolyl]-N,O-dimethyl-, phi-lactone (9CI), L-Tyrosine, N-[1-[N-[4-[[3-Hydroxy-4-[[N-[N-[1-(2-hydroxy-1-oxopropyl)- L-prolyl]-N-methyl-L-leucyl]-L-threonyl]amino-5-methyl-1-oxoheptyl]oxy]-2,5-dimethyl-1,3-dioxohexyl]-L-leucyl]- L-prolyl]-N,O-dimethyl-, .phi.-lactone (9CI), Didemnin 
A cyclic depsipeptide extracted from the Caribbean tunicate Trididemnum cyanophorum. Didemnin B activates caspase, thereby inducing apoptosis, and… 
National Institutes of Health

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Papers overview

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2001
2001
Mitochondrial cytochrome c release is caspase-dependent and does not involve mitochondrial permeability transition in didemnin B-induced apoptosis
Permeability transition, and a subsequent drop in mitochondrial membrane potential (ΔΨm), have been suggested to be mechanisms by… 
1996
1996
Didemnin binds to the protein palmitoyl thioesterase responsible for infantile neuronal ceroid lipofuscinosis.
The marine natural product didemnin B, currently in clinical trials as an antitumor agent, has several potent biological… 
1996
1996
Synthetic Routes to a Constrained Ring Analog of Didemnin B.
The didemnin class of biologically active cyclodepsipeptides, isolated from a marine tunicate, has shown antitumor, antiviral… 
Highly Cited
1995
Highly Cited
1995
Normal moveout from dipping reflectors in anisotropic media
Description of reflection moveout from dipping interfaces is important in developing seismic processing methods for anisotropic… 
1995
1995
Didemnin B induces cell death by apoptosis: the fastest induction of apoptosis ever described.
Didemnin B, a cyclic N-methylated peptolide induces apoptosis in human HL-60 cells. When incubated with 1 microM didemnin B… 
Highly Cited
1989
Highly Cited
1989
Evaluation of glycolamide esters and various other esters of aspirin as true aspirin prodrugs.
A series of glycolamide, glycolate, (acyloxy)methyl, alkyl, and aryl esters of acetylsalicylic acid (aspirin) were synthesized… 
Highly Cited
1985
Highly Cited
1985
DIDEMNIN B: A NEW IMMUNOSUPPRESSIVE CYCLIC PEPTIDE WITH POTENT ACTIVITY IN VITRO AND IN VIVO
Didemnin B (DB) is a 7-amino-acid, cyclic polypeptide with potent (10−7-10−10M) antiproliferative effects in vivo and in vitro… 
1982
1982
Geno- and cytotoxicity of nitrosamines, aflatoxin B1, and benzo[a]-pyrene in continuous cultures of rat hepatoma cells.
Two closely related hepatoma cell lines were examined for their response to carcinogens requiring metabolic activation: H5, a… 
1972
1972
Effect of complex formation on drug absorption. XII. Enhancement of intestinal absorption of prednisone and prednisolone by dialkylpropionamides in rats.
The effect of N,N-dimethyl-, N,N-diethyl-, N,N-di-n-propyl-, and N,N-di-n-butylpropionamide on the absorption of prednisone and… 
1964
1964
Erzeugung von Krebs durch eine einmalige Dosis von Methylnitroso-Harnstoff und verschiedenen Dialkylnitrosaminen an Ratten
Nach früheren Ergebnissen wächst die carcinogene Wirkung bei täglicher Gabe konstanter Dosen etwa mit dem Quadrat der… 
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