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didemnin B

Known as: L-Tyrosine, N-[1-[N-[4-[[3-Hydroxy-4-[[N-[N-[1-(2-hydroxy-1-oxopropyl)- L-prolyl]-N-methyl-L-leucyl]-L-threonyl]amino]-5-methyl-1-oxoheptyl]oxy]-2,5-dimethyl-1,3-dioxohexyl]-L-leucyl]- L-prolyl]-N,O-dimethyl-, phi-lactone (9CI), L-Tyrosine, N-[1-[N-[4-[[3-Hydroxy-4-[[N-[N-[1-(2-hydroxy-1-oxopropyl)- L-prolyl]-N-methyl-L-leucyl]-L-threonyl]amino-5-methyl-1-oxoheptyl]oxy]-2,5-dimethyl-1,3-dioxohexyl]-L-leucyl]- L-prolyl]-N,O-dimethyl-, .phi.-lactone (9CI), Didemnin 
A cyclic depsipeptide extracted from the Caribbean tunicate Trididemnum cyanophorum. Didemnin B activates caspase, thereby inducing apoptosis, and… 
National Institutes of Health

Papers overview

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Review
2018
Review
2018
This paper describes the substances of plant and marine origin that have anticancer properties. The chemical structure of the… 
Highly Cited
2015
Highly Cited
2012
Highly Cited
2012
The anti-neoplastic agent didemnin B from the Caribbean tunicate Trididemnum solidum was the first marine drug to be clinically… 
Highly Cited
2011
Highly Cited
2011
Natural products obtained from marine invertebrates such as sponges and tunicates are attractive sources of drugs. However, a… 
Highly Cited
2010
Highly Cited
2010
A number of natural products from marine sponges, such as cyclodepsipeptides, have been identified. The structural… 
Highly Cited
2006
Highly Cited
2006
Molecular dynamics (MD) simulations have been performed on N-methyl-N-propylpyrrolidinium bis(trifluoromethanesulfonyl)imide… 
Highly Cited
2004
Highly Cited
2004
Tris(2-carboxyethyl)phosphine (TCEP) is a widely used substitute for dithiothreitol (DTT) in the reduction of disulfide bonds in… 
Review
1988
Review
1988
Didemnins A, B, and C, cyclic depsipeptides previously reported by our laboratory from the Caribbean tunicate Trididemnum solidum… 
Highly Cited
1981
Highly Cited
1981
Extracts of samples of a Caribbean tunicate (ascidian, sea squirt) of the family Didemnidae inhibit in vitro at low…