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Pharmacologic target‐mediated drug disposition
- G. Levy
- Biology, PsychologyClinical pharmacology and therapeutics
- 1 September 1994
Clinical Pharmacology and Therapeutics (1994) 56, 248–252; doi:10.1038/clpt.1994.134
Kinetics of pharmacologic effects
- G. Levy
- Medicine, BiologyClinical pharmacology and therapeutics
- 1 May 1966
Pharmacokinetic analysis of pharmacologic activity data can lead to better understanding of the relationship between dose and the multiple pharmacologic effects elicited by a drug, and it can facilitate the assessment of factors which account for individual variations in the response to drugs.
Limited capacity for salicyl phenolic glucuronide formation and its effect on the kinetics of salicylate elimination in man
Evidence is presented which shows that man has a limited capacity to form salicyl phenolic glucuronide from salicylic acid and that this process is describable by Michaelis‐Menten kinetics in the…
Effect of heparin or salicylate infusion on serum protein binding and on concentrations of phenytoin in serum, brain and cerebrospinal fluid of rats.
It is concluded that the apparent displacement of phenytoin from plasma proteins occurs in vitro, after collection of blood samples from heparinized animals.
Kinetics of drug action in disease states. XIV. Effect of infusion rate on pentylenetetrazol concentrations in serum, brain and cerebrospinal fluid of rats at onset of convulsions.
A method which can be used to determine the effect of various diseases on the concentration-pharmacologic activity relationship of the central nervous system stimulant pentylenetetrazol (PTZ, Metrazol) in a manner that excludes or accounts for pharmacokinetic variables is developed.
Absorption of orally administered sodium sulfate in humans.
A large amount of sodium sulfate, when administered orally in divided doses over 3 hr, is well tolerated and is absorbed to a significant extent and may be useful for the early treatment of acetaminophen overdose.
Pharmacokinetics of salicylate elimination in man.
- G. Levy
- Biology, ChemistryJournal of pharmaceutical sciences
- 1 July 1965
The pharmacokinetics of salicylate elimination were found to be unusual both qualitatively and quantitatively, and the results of the present study have potentially important therapeutic, toxicologic, and pharmacogenetic implications.
Serum concentration and renal excretion by normal adults of inorganic sulfate after acetaminophen, ascorbic acid, or sodium sulfate
The renal tubular reabsorption of inorganic sulfate is capacity limited, as evidenced by the decrease of the reabsorbed fraction with increasing glomerular filtration rate of the anion, which facilitates sulfate homeostasis.
Kinetics of drug action in disease states. XVI. Pharmacodynamics of theophylline-induced seizures in rats.
An animal model suitable for exploring conditions that might predispose theophylline-treated individuals to seizures is developed and direct i.v. infusion of either 1-methyluric acid, 1,3-dimethyluric Acid or 3-methylxanthine did not produce seizures despite high concentrations in serum, and Ethylenediamine infusions also did not cause seizures.