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desmethylmianserin

National Institutes of Health

Related topics

Related topics

3 relations

Broader (1)

Mianserin

Narrower (1)

Org OH 46
analogs & derivatives

Papers overview

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Highly Cited
2006
Highly Cited
2006
A Fully Automated Turbulent-Flow Liquid Chromatography-Tandem Mass Spectrometry Technique for Monitoring Antidepressants in Human Serum
Antidepressants belong to a variety of chemical and pharmacologic classes. Most require therapeutic drug monitoring, at least in… 
2006
2006
Lack of effect of mianserin on the symptoms of diabetic neuropathy
SummaryThe effect of the non-tricyclic antidepressant mianserin on symptoms of diabetic neuropathy has been studied in 18… 
1998
1998
Steady state concentrations of the enantiomers of mianserin and desmethylmianserin in poor and in homozygous and heterozygous extensive metabolizers of debrisoquine.
Steady state concentrations of (S)- and (R)-mianserin and desmethylmianserin were measured in 21 homozygous extensive… 
1997
1997
Effects of thioridazine, an inhibitor of CYP2D6, on the steady-state plasma concentrations of the enantiomers of mianserin and its active metabolite, desmethylmianserin, in depressed Japanese…
The antidepressant mianserin is administered as a racemate of the S(+)- and R(-)-enantiomers. Previous in-vitro studies have… 
1995
1995
Enantioselective Determination of Mianserin and Its Desmethyl Metabolite in Plasma During Treatment of Depressed Japanese Patients
Summary A method for the analysis of the enantiomers of mianserin and its main metabolite desmethylmianserin in plasma using a… 
1994
1994
Determination of the enantiomers of mianserin, desmethylmianserin, and 8-hydroxymianserin in the plasma and urine of mianserin-treated patients.
An HPLC method is presented which allows the measurement in the same run of the enantiomers of mianserin, desmethylmianserin, and… 
1989
1989
Activation of mianserin and its metabolites by human liver microsomes.
1989
1989
A stereochemical investigation of the cytotoxicity of mianserin metabolites in vitro.
1. The metabolism of the enantiomers of mianserin to stable, chemically reactive and cytotoxic metabolites by human liver… 
1987
1987
The effect of chronically administered mianserin, 8-hydroxymianserin and desmethylmianserin on the 'open field' behaviour and brain noradrenaline metabolism in the olfactory bulbectomized rat.
The chronic effects of mianserin and two of its major metabolites on the behaviour of olfactory bulbectomized rats in the 'open… 
1982
1982
Determination of mianserin and metabolites in plasma by liquid chromatography with electrochemical detection.
A procedure for the determination of mianserin, desmethylmianserin, and 8-hydroxymianserin in plasma at therapeutic… 
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