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Low daily 10‐mg and 20‐mg doses of fluvoxamine inhibit the metabolism of both caffeine (cytochrome P4501A2) and omeprazole (cytochrome P4502C19)
TLDR
Whether nontherapeutic doses of fluvoxamine inhibit CYP1A2 but possibly not CYP2C19 is investigated. Expand
Effects of various factors on steady state plasma concentrations of trazodone and its active metabolite m-chlorophenylpiperazine.
TLDR
There is a large Interindividual variation in the metabolism of trazodone, which suggests that smoking enhances the metabolism, but age, sex and co-administration of benzodiazepines do not affect it; and traZodone and mCPP have linear kinetics. Expand
Stereospecific analysis of omeprazole supports artemisinin as a potent inducer of CYP2C19
TLDR
The results support and strengthen earlier findings that artemisinin induces CYP2C19 as well as at least one enzyme other than CYP3A4 and strengthen the belief that the antimalarial artemis inin induces a different enzyme in addition to CYP 2C19. Expand
Effects of the CYP2D6*10 allele on the steady‐state plasma concentrations of haloperidol and reduced haloperidol in Japanese patients with schizophrenia
TLDR
The CYP2D6*10 (*10) allele is present in Asians with a high frequency of about 50% and the effects of the *10 allele on the steady‐state plasma concentrations (Css) of haloperidol and reduced haloperIDol are studied. Expand
Association of the TaqI A polymorphism of the dopamine D(2) receptor gene with predisposition to neuroleptic malignant syndrome.
TLDR
Findings suggest that the TaqI A DRD(2) polymorphism is associated with the predisposition to neuroleptic malignant syndrome. Expand
Prolactin response to nemonapride, a selective antagonist for D2 like dopamine receptors, in schizophrenic patients in relation to Taq1A polymorphism of DRD2 gene
TLDR
It is suggested that female patients with the A1 allele show a greater prolactin response to nemonapride, who may have a high risk for adverse effects associated with neuroleptic-induced hyperprolactinemia. Expand
Effects of CYP2D6 Genotypes on Plasma Concentrations of Risperidone and Enantiomers of 9‐Hydroxyrisperidone in Japanese Patients with Schizophrenia
TLDR
It is suggested that CYP2D6 activity strongly influences the steady‐state plasma concentrations of risperidone and ris peridone/9‐hydroxyrisperidones concentration ratios but is unlikely to determine enantioselectivity in the steady-state plasma concentration of 9‐Hydroxyr isperid one in the clinical situation. Expand
Relationship Between Plasma Concentrations of Trazodone and Its Active Metabolite, m-Chlorophenylpiperazine, and Its Clinical Effect in Depressed Patients
TLDR
It is suggested that a therapeutic response is dependent on the plasma concentration of trazodone but not m-CPP and that a plasma traZodone concentration of about 700 ng/mL may be a threshold for a good therapeutic response. Expand
The CYP2D6 genotype and plasma concentrations of mianserin enantiomers in relation to therapeutic response to mianserin in depressed Japanese patients.
TLDR
The study presented here suggests that the CYP2D6 genotype plays a major role in controlling plasma concentration of the S-enantiomer of mianserin, which contributes to a major extent to the antidepressant effect during mianserserin treatment. Expand
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