T. Cooper

Publications431
h-index72
Citations21,230
Highly Influential Citations620
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Increased baseline occupancy of D2 receptors by dopamine in schizophrenia.
TLDR
Elevated synaptic dopamine was predictive of good treatment response of positive symptoms to antipsychotic drugs and increased stimulation of D(2) receptors by dopamine in schizophrenia, consistent with increased phasic activity of dopaminergic neurons.
Continuation pharmacotherapy in the prevention of relapse following electroconvulsive therapy: a randomized controlled trial.
TLDR
It is indicated that without active treatment, virtually all remitted patients relapse within 6 months of stopping ECT, and the combination of nortriptyline and lithium is more effective, but the relapse rate is still high, particularly during the first month of continuation therapy.
Delta-9-tetrahydrocannabinol effects in schizophrenia: Implications for cognition, psychosis, and addiction
Circadian time of morning light administration and therapeutic response in winter depression.
TLDR
The antidepressant effect of light is potentiated by early-morning administration in circadian time, optimally about 8.5 hours after melatonin onset or 2.
Double-blind and placebo-controlled study of lithium for adolescent bipolar disorders with secondary substance dependency.
TLDR
Lithium treatment of BP with secondary SDD in adolescents was an efficacious treatment for both disorders and warrant replication with a long-term maintenance phase.
Serotonergic studies in patients with affective and personality disorders. Correlates with suicidal and impulsive aggressive behavior.
TLDR
It is suggested that reduced central serotonergic function is present in a subgroup of patients with major affective and/or personality disorder and is associated with history of suicide attempt in patients with either disorder, but with impulsive aggression in Patients with personality disorder only.
Neurocognitive effects of clozapine, olanzapine, risperidone, and haloperidol in patients with chronic schizophrenia or schizoaffective disorder.
TLDR
Patients with a history of suboptimal response to conventional treatments may show cognitive benefits from newer antipsychotic drugs, and there may be differences between atypical antipsychotics drugs in their patterns of cognitive effects.
Changes in glucose and cholesterol levels in patients with schizophrenia treated with typical or atypical antipsychotics.
TLDR
In this prospective randomized trial, clozAPine, olanzapine, and haloperidol were associated with an increase of plasma glucose level, and clozapine and olanZapine were associatedWith an increase in cholesterol levels.
Fluoxetine-elicited changes in brain neurosteroid content measured by negative ion mass fragmentography.
Fluoxetine administered intraperitoneally to sham-operated or adrenalectomized/castrated (ADX/CX) male rats dose-dependently (2.9-58 mumol/kg i.p.) increased the brain content of the neurosteroid 3…
Effect of chronic ethanol exposure and its withdrawal on the endocannabinoid system
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