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Increased baseline occupancy of D2 receptors by dopamine in schizophrenia.
Elevated synaptic dopamine was predictive of good treatment response of positive symptoms to antipsychotic drugs and increased stimulation of D(2) receptors by dopamine in schizophrenia, consistent with increased phasic activity of dopaminergic neurons.
Continuation pharmacotherapy in the prevention of relapse following electroconvulsive therapy: a randomized controlled trial.
It is indicated that without active treatment, virtually all remitted patients relapse within 6 months of stopping ECT, and the combination of nortriptyline and lithium is more effective, but the relapse rate is still high, particularly during the first month of continuation therapy.
Circadian time of morning light administration and therapeutic response in winter depression.
The antidepressant effect of light is potentiated by early-morning administration in circadian time, optimally about 8.5 hours after melatonin onset or 2.
Double-blind and placebo-controlled study of lithium for adolescent bipolar disorders with secondary substance dependency.
Lithium treatment of BP with secondary SDD in adolescents was an efficacious treatment for both disorders and warrant replication with a long-term maintenance phase.
Serotonergic studies in patients with affective and personality disorders. Correlates with suicidal and impulsive aggressive behavior.
It is suggested that reduced central serotonergic function is present in a subgroup of patients with major affective and/or personality disorder and is associated with history of suicide attempt in patients with either disorder, but with impulsive aggression in Patients with personality disorder only.
Neurocognitive effects of clozapine, olanzapine, risperidone, and haloperidol in patients with chronic schizophrenia or schizoaffective disorder.
Patients with a history of suboptimal response to conventional treatments may show cognitive benefits from newer antipsychotic drugs, and there may be differences between atypical antipsychotics drugs in their patterns of cognitive effects.
Changes in glucose and cholesterol levels in patients with schizophrenia treated with typical or atypical antipsychotics.
In this prospective randomized trial, clozAPine, olanzapine, and haloperidol were associated with an increase of plasma glucose level, and clozapine and olanZapine were associatedWith an increase in cholesterol levels.
Fluoxetine-elicited changes in brain neurosteroid content measured by negative ion mass fragmentography.
Fluoxetine administered intraperitoneally to sham-operated or adrenalectomized/castrated (ADX/CX) male rats dose-dependently (2.9-58 mumol/kg i.p.) increased the brain content of the neurosteroid 3