denosumab

Known as: Denosumab [Chemical/Ingredient], Densosumab 
A fully human monoclonal antibody directed against the receptor activator of nuclear factor kappa beta ligand (RANKL) with antiosteoclast activity… (More)
National Institutes of Health

Papers overview

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Review
2017
Review
2017
BACKGROUND Bone is the most common site of metastatic disease associated with breast cancer (BC). Bisphosphonates inhibit… (More)
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Review
2017
Review
2017
We aimed to study the clinical and imaging characteristics of patients sustaining vertebral fractures after denosumab… (More)
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Highly Cited
2012
Highly Cited
2012
BACKGROUND Bone metastases are a major cause of morbidity and mortality in men with prostate cancer. Preclinical studies suggest… (More)
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Highly Cited
2011
Highly Cited
2011
BACKGROUND Bone metastases are a major burden in men with advanced prostate cancer. We compared denosumab, a human monoclonal… (More)
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Highly Cited
2010
Highly Cited
2010
PURPOSE This randomized study compared denosumab, a fully human monoclonal antibody against receptor activator of nuclear factor… (More)
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Highly Cited
2010
Highly Cited
2010
BACKGROUND Giant-cell tumour (GCT) of bone is a primary osteolytic bone tumour with low metastatic potential and is associated… (More)
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Highly Cited
2009
Highly Cited
2009
BACKGROUND Denosumab is a fully human monoclonal antibody to the receptor activator of nuclear factor-kappaB ligand (RANKL) that… (More)
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Highly Cited
2009
Highly Cited
2009
BACKGROUND Androgen-deprivation therapy is well-established for treating prostate cancer but is associated with bone loss and an… (More)
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Highly Cited
2009
Highly Cited
2009
PURPOSE Patients with bone metastases and elevated urinary N-telopeptide (uNTx), representing excessive bone resorption, are at… (More)
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Highly Cited
2008
Highly Cited
2008
CONTEXT Denosumab is an investigational fully human monoclonal antibody against receptor activator of nuclear factor-kappaB… (More)
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