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2012 American College of Rheumatology guidelines for management of gout. Part 1: Systematic nonpharmacologic and pharmacologic therapeutic approaches to hyperuricemia
DINESH KHANNA, JOHN D. FITZGERALD, PUJA P. KHANNA, SANGMEE BAE, MANJIT K. SINGH, TUHINA NEOGI, MICHAEL H. PILLINGER, JOAN MERILL, SUSAN LEE, SHRADDHA PRAKASH, MARIAN KALDAS, MANEESH GOGIA, FERNANDOExpand
2012 American College of Rheumatology guidelines for management of gout. Part 2: Therapy and antiinflammatory prophylaxis of acute gouty arthritis
TLDR
These guidelines for the management and anti-inflammatory prophylaxis of acute attacks of gouty arthritis complements the manuscript on guidelines to treat hyperuricemia in patients with evidence of gouts and involves a diverse and international panel of experts. Expand
2015 Gout classification criteria: an American College of Rheumatology/European League Against Rheumatism collaborative initiative
TLDR
The new classification criteria, developed using a data-driven and decision-analytic approach, have excellent performance characteristics and incorporate current state-of-the-art evidence regarding gout. Expand
National prevalence of gout derived from administrative health data in Aotearoa New Zealand.
TLDR
Applying algorithms to national administrative data sets provides a readily available method for estimating the prevalence of a chronic condition such as gout, where diagnosis and drug treatment are relatively specific for this disease. Expand
Mechanisms of inflammation in gout.
TLDR
This review article outlines recent advances in the understanding of the mechanisms of inflammation in gout and proposes a unifying model of gout involving the differential role of mononuclear phagocytes in the regulation of the inflammatory response to MSU crystals. Expand
Starting dose is a risk factor for allopurinol hypersensitivity syndrome: a proposed safe starting dose of allopurinol.
TLDR
It is indicated that starting allopurinol at a dose of 1.5 mg per unit of estimated GFR may be associated with a reduced risk of AHS, and the dose can be gradually increased to achieve the target serum urate level. Expand
A subset of natural killer cells is greatly expanded within inflamed joints.
TLDR
The study showed that the CD3-, CD56(bright) subset of NK cells was greatly expanded within inflamed joints and rendered them good candidates for a role in interacting with the macrophage/monocyte population within the joint, thus amplifying the production of proinflammatory cytokines. Expand
A strong role for the ABCG2 gene in susceptibility to gout in New Zealand Pacific Island and Caucasian, but not Māori, case and control sample sets.
TLDR
The results emphasize the need to account for sub-population differences when undertaking biomedical genetic research in a group defined by a geographical region and shared ancestry but characterized by migratory events that create bottlenecks and altered genetic structure in the founder populations. Expand
Association of variation in Fcγ receptor 3B gene copy number with rheumatoid arthritis in Caucasian samples
TLDR
One possible mechanism to explain the association between reduced FCGR3B CN and RA is the reduced clearance of immune complex during inflammation. Expand
The Experience and Impact of Living With Gout: A Study of Men With Chronic Gout Using a Qualitative Grounded Theory Approach
TLDR
Previously hidden perspectives of the experience of gout are provided, suggesting that shame, embarrassment, and stigma lead to trivialization of the impact of disease despite its severity, which could contribute to the development of progressive gout. Expand
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