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delanzomib

Known as: ((1R)-1-((2S,3R)-3-hydroxy-2-(6-phenylpyridine-2-carboxamido)butanamido)-3-methylbutyl)boronic Acid 
An orally bioavailable synthetic P2 threonine boronic acid inhibitor of the chymotrypsin-like activity of the proteasome, with potential… 
National Institutes of Health

Related topics

Related topics

6 relations

Broader (3)

Boronic AcidsProteasome inhibitorThreonine

Narrower (1)

CEP-18770
NCIt Antineoplastic Agent Terminologyanalogs & derivatives

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2019
Review
2019
Proteasome Inhibitors as Sensitizing Agents for Cancer Chemotherapy
2018
2018
Progress curve analysis of the kinetics of slow-binding anticancer drug inhibitors of the 20S proteasome.
2018
2018
Myocyte-Damaging Effects and Binding Kinetics of Boronic Acid and Epoxyketone Proteasomal-Targeted Drugs
The proteasome inhibitors bortezomib, carfilzomib, and ixazomib, which are used in the treatment of multiple myeloma have greatly… 
2018
2018
Abstract 1878: Molecular mechanisms of the cardiotoxicity of the proteasomal-targeted anticancer drugs bortezomib, carfilzomib, ixazomib, oprozomib, and delanzomib
  • B. Hasinoff
  • Experimental and Molecular Therapeutics
  • 2018
  • Corpus ID: 81429618
Bortezomib, carfilzomib, ixazomib, oprozomib, and delanzomib are anticancer drugs that target the proteasomal system. Bortezomib… 
2016
2016
122 Ritonavir and delanzomib inhibit renal cancer growth in vitro and in vivo by inducing endoplasmic reticulum stress synergistically
Review
2015
Review
2015
[Proteasome inhibitors in cancer therapy].
Proteasomes are multisubunit enzyme complexes. They contain three enzymatic active sites which are termed chymotrypsin-like… 
2015
2015
Kanser tedavisinde proteozom inhibitörlerinin önemi
Son yillarda ubikutin-proteozom sistemi, hucre buyumesi ve olumu arasinda denge, insan malignansilerinin ilerlemesi ve kanser… 
Review
2015
Review
2015
Networks regulating ubiquitin and ubiquitin-like proteins promise new therapeutic targets.
The 2004 Nobel Prize in Chemistry jointly awarded to Aaron Ciechanover, Avram Hershko and Irwin Rose celebrated the significance… 
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