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Causes and consequences of DNA hypomethylation in human cancer.
Because of their relation to tumor progression and metastasis, DNA hypomethylation markers may be particularly useful to classify cancer and predict their clinical course. Expand
Association of NAD(P)H: quinone oxidoreductase 1 (NQO1) C609T polymorphism with esophageal squamous cell carcinoma in a German Caucasian and a northern Chinese population.
The association of the NQO1 C609T polymorphism with ESCC in genetically distinct populations makes a strong argument for its importance in carcinogenesis of ES CC in the German Caucasian and the northern Chinese population. Expand
Glutathione transferase isozyme genotypes in patients with prostate and bladder carcinoma
Findings suggest that specific single polymorphic GST genes, that is GSTM1 in the case of bladder cancer and GSTT1 inThe case of prostatic carcinoma, are most relevant for the development of these urological malignancies among the general population in Central Europe. Expand
DKC1 overexpression associated with prostate cancer progression
DKC1 upregulation in prostate cancers is common and likely to be necessary for extensive tumour growth, and the phenotype of prostate carcinoma cell lines after dyskerin downregulation suggests that its most critical function is sustaining protein biosynthesis. Expand
Epigenetic control of CTCFL/BORIS and OCT4 expression in urogenital malignancies.
In prostate and bladder carcinoma cell lines and cancer tissues expression remained largely unchanged, but individual prostate carcinomas showed modestly increased CTCFL expression compared to normal tissues, implying that inhibitors of DNA methylation used for cancer treatment may induce C TCFL expression. Expand
Molecular Biology of Human Cancers: An Advanced Student's Textbook
Pretreatment Considerations Basic Treatment Considerations Current Treatment Strategies in Non-Small Cell Lung Cancer: Early Stage in Non-Small Cell Lung Cancer Locally Advanced Non-Small Cell LungExpand
DNA methylation and expression of LINE-1 and HERV-K provirus sequences in urothelial and renal cell carcinomas
It is speculated that decreased methylation of LINE-1 retroelements, in particular, may contribute to genomic instability in specific human tumours such as urothelial carcinoma by rendering these normally repressed sequences competent for transcription and recombination. Expand
Methyl group metabolism gene polymorphisms and susceptibility to prostatic carcinoma
Heterozygosity or heterozygosity for such weaker alleles of genes for its synthesis may underlie susceptibility to prostatic carcinoma. Expand
Association between NAD(P)H: Quinone oxidoreductase 1 (NQ01) inactivating C609T polymorphism and adenocarcinoma of the upper gastrointestinal tract
Determination of the NQO1 genotype may gain importance as a stratification marker in future prevention trials for adenocarcinoma of upper gastrointestinal tract because of its association with susceptibility to tumours induced by chemical carcinogens. Expand
Understanding urothelial carcinoma through cancer pathways
  • W. Schulz
  • Biology, Medicine
  • International journal of cancer
  • 1 October 2006
It is argued that a ‘cancer pathway’ perspective is useful to integrate findings from both candidate gene and genome‐wide approaches to study UC molecular biology, and neither canonical WNT/β‐Catenin nor hedgehog signaling appear to play major roles in UC. Expand