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Causes and consequences of DNA hypomethylation in human cancer.
While specific genes are hypermethylated in the genome of cancer cells, overall methylcytosine content is often decreased as a consequence of hypomethylation affecting many repetitive sequences.Expand
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Association of NAD(P)H: quinone oxidoreductase 1 (NQO1) C609T polymorphism with esophageal squamous cell carcinoma in a German Caucasian and a northern Chinese population.
NAD(P)H: quinone oxidoreductase 1 (NQO1) is an antioxidant enzyme, important in the detoxification of environmental carcinogens. A single base substitution (C --> T) polymorphism at nucleotide 609Expand
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Glutathione transferase isozyme genotypes in patients with prostate and bladder carcinoma
Abstract. Genotype distributions for GSTP1, GSTM1, and GSTT1 were determined in 91 patients with prostatic carcinoma and 135 patients with bladder carcinoma and compared with those in 127 abdominalExpand
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Epigenetic control of CTCFL/BORIS and OCT4 expression in urogenital malignancies.
Aberrant hypomethylation in many cancers reactivates retrotransposons and selected single-copy genes such as cancer-testis antigens. Genes reactivated in this manner have recently been postulated toExpand
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Molecular Biology of Human Cancers: An Advanced Student's Textbook
Pretreatment Considerations Basic Treatment Considerations Current Treatment Strategies in Non-Small Cell Lung Cancer: Early Stage in Non-Small Cell Lung Cancer Locally Advanced Non-Small Cell LungExpand
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Methyl group metabolism gene polymorphisms and susceptibility to prostatic carcinoma.
BACKGROUND Alterations of DNA methylation are very frequent in prostatic carcinoma. A possible cause underlying altered DNA methylation could be an insufficient level of S-adenosylmethionine as aExpand
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DKC1 overexpression associated with prostate cancer progression
Background:Dyskerin encoded by the DKC1 gene is a predominantly nucleolar protein essential for the formation of pseudouridine in RNA and the telomerase RNA subunit hTR. Inherited mutationsExpand
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Association between NAD(P)H: Quinone oxidoreductase 1 (NQ01) inactivating C609T polymorphism and adenocarcinoma of the upper gastrointestinal tract
NQO1 is an antioxidant enzyme, important in the detoxification of environmental carcinogens. A single nucleotide polymorphism (C→T) at position 609 of the NQO1 cDNA has been associated withExpand
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Tornadoes Associated with Cyclones of Tropical Origin-Practical Features
Abstract The frequency of reports of tornadoes associated with tropical cyclones is shown to have increased during the past decade to a level worthy of professional attention. Tornado incidence isExpand
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DNA methylation and expression of LINE-1 and HERV-K provirus sequences in urothelial and renal cell carcinomas
SummarySince DNA methylation is considered an important mechanism for silencing of retroelements in the mammalian genome, hypomethylation in human tumours may lead to their reactivation. TheExpand
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