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The reversible phosphorylation of proteins is accomplished by opposing activities of kinases and phosphatases. Relatively few… Expand The target of rapamycin (TOR) is a conserved Ser/Thr kinase that regulates cell growth and metabolism in response to… Expand Cancers arise owing to the accumulation of mutations in critical genes that alter normal programmes of cell proliferation… Expand MAP kinases are evolutionarily conserved proteins that are activated by a protein kinase cascade, including a MAP kinase kinase… Expand Activation of the nuclear transcription factor NF-κB by inflammatory cytokines requires the successive action of NF-κB-inducing… Expand Studies of hereditary cancer syndromes have contributed greatly to our understanding of molecular events involved in… Expand A signaling pathway was delineated by which insulin-like growth factor 1 (IGF-1) promotes the survival of cerebellar neurons. IGF… Expand Protein kinases activated by dual phosphorylation on Tyr and Thr (MAP kinases) can be grouped into two major classes: ERK and JNK… Expand We have identified proteins that interact with H-Ras using a two hybrid system screen of a mouse cDNA library. Approximately 50… Expand We recently described the purification and cloning of extracellular signal-regulated kinase 1 (ERK1), which appears to play a… Expand