• Publications
  • Influence
Regulation of distinct AMPA receptor phosphorylation sites during bidirectional synaptic plasticity
TLDR
It is shown that LTP and LTD reversibly modify the phosphorylation of the AMPA receptor GluR1 subunit, and that identical stimulation conditions recruit different signal-transduction pathways depending on synaptic history. Expand
PKA phosphorylation of AMPA receptor subunits controls synaptic trafficking underlying plasticity
TLDR
It is found that PKA phosphorylation of the AMPA receptor subunits GluR4 and GLUR1 directly controlled the synaptic incorporation of AMPA receptors in organotypic slices from rat hippocampus. Expand
GRIP: a synaptic PDZ domain-containing protein that interacts with AMPA receptors
TLDR
GRIP is a new member of the PDZ domain-containing protein family which has seven PDZ domains and no catalytic domain and appears to serve as an adapter protein that links AMPA receptors to other proteins and may be critical for the clustering of AMPA receptor at excitatory synapses in the brain. Expand
MAPK cascade signalling and synaptic plasticity
TLDR
This work has reported the involvement of a 'parallel' but distinct kinase cascade leading to the activation of p38 MAPK, which might control distinct forms of synaptic plasticity in the adult brain. Expand
Characterization of Multiple Phosphorylation Sites on the AMPA Receptor GluR1 Subunit
TLDR
The modulation of GluR1 by PKA phosphorylated of Ser-845 suggests that phosphorylation of this residue may underlie the PKA-induced potentiation of AMPA receptors in neurons. Expand
Phosphorylation of the AMPA Receptor Subunit GluR2 Differentially Regulates Its Interaction with PDZ Domain-Containing Proteins
TLDR
It is shown that PKC phosphorylation of the AMPA receptor GluR2 subunit differentially modulates its interaction with the PDZ domain-containing proteins GRIP1 and PICK1. Expand
Elongation Factor 2 and Fragile X Mental Retardation Protein Control the Dynamic Translation of Arc/Arg3.1 Essential for mGluR-LTD
TLDR
It is demonstrated that Arc/Arg3.1 is translationally induced within 5 min of mGluR activation, and this response is essential for mGLUR-dependent LTD, and a model in which eEF2K-eEF2 and FMRP coordinately control the dynamic translation of Arc/ Arg3. Expand
The cell biology of synaptic plasticity: AMPA receptor trafficking.
TLDR
The life cycle of AMPARs is described, from their biogenesis, through their journey to the synapse, and ultimately through their demise, and how the modulation of this process is essential for brain function is discussed. Expand
Arc/Arg3.1 Mediates Homeostatic Synaptic Scaling of AMPA Receptors
TLDR
It is demonstrated that Arc/Arg3.1, an immediate-early gene that is rapidly induced by neuronal activity associated with information encoding in the brain, mediates homeostatic synaptic scaling of AMPA type glutamate receptors (AMPARs) via its ability to activate a novel and selective AMPAR endocytic pathway. Expand
Phosphorylation of the AMPA Receptor GluR1 Subunit Is Required for Synaptic Plasticity and Retention of Spatial Memory
TLDR
It is demonstrated that phosphorylation of GluR1 is critical for LTD and LTP expression and the retention of memories. Expand
...
1
2
3
4
5
...