Proteasome inhibitor

Known as: Inhibitor, Proteasome, Inhibitors, Proteasome, Proteasome Endopeptidase Complex Inhibitors 
Any substance that inhibits the proteasome complex, an enzyme complex responsible for degradation of ubiquitinated proteins. Inhibition of proteasome… (More)
National Institutes of Health

Papers overview

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Review
2008
Review
2008
The ubiquitin-proteasome pathway is involved in intracellular protein turnover, and its function is crucial to cellular… (More)
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Highly Cited
2008
Highly Cited
2008
Autoantibody-mediated diseases like myasthenia gravis, autoimmune hemolytic anemia and systemic lupus erythematosus represent a… (More)
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Highly Cited
2007
Highly Cited
2007
Two major protein degradation systems exist in cells, the ubiquitin proteasome system and the autophagy machinery. Here, we… (More)
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Highly Cited
2006
Highly Cited
2006
Multiple myeloma (MM) is an incurable plasma cell malignancy. The 26S proteasome inhibitor, bortezomib, selectively induces… (More)
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Highly Cited
2004
Highly Cited
2004
Environmental toxins have been implicated in the etiology of Parkinson's disease. Recent findings of defects in the ubiquitin… (More)
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Highly Cited
2002
Highly Cited
2002
One hypothesis for the etiology of Parkinson's disease (PD) is that subsets of neurons are vulnerable to a failure in proteasome… (More)
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Highly Cited
1999
Highly Cited
1999
The ubiquitin-proteasome pathway plays a critical role in the regulated degradation of proteins involved in cell cycle control… (More)
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Highly Cited
1997
Highly Cited
1997
The hypoxia-inducible factor 1 transcriptional activator complex (HIF-1) is involved in the activation of the erythropoietin and… (More)
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Highly Cited
1997
Highly Cited
1997
Proteolysis by the ubiquitin/proteasome pathway controls the intracellular levels of a number of proteins that regulate cell… (More)
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Highly Cited
1995
Highly Cited
1995
Most cases of cystic fibrosis are caused by mutations that interfere with the biosynthetic folding of the cystic fibrosis… (More)
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