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curacin C

The C isomer of Curacin compound. Cruacin C inhibits tubulin polymerization, thereby inhibiting mitosis and cell proliferation. (NCI)
National Institutes of Health

Papers overview

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2017
2017
A bioactivity guided study of a cf. Caldora penicillata species, collected during a 2013 expedition to the Pacific island of… Expand
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2016
2016
Bioassay-guided fractionation of the extract of the brittle star Ophiocoma scolopendrina afforded curacin E (1), a congener of… Expand
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2015
2015
The natural product curacin A, a potent anticancer agent, contains a rare cyclopropane group. The five enzymes for cyclopropane… Expand
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Review
2012
Review
2012
................................................................................................................................... xiii Chapter 1 Introduction .......................................................................................................... 1 Background ......................................................................................................................................... 1 Curacin A .............................................................................................................................................. 1 Biosynthesis of natural products ................................................................................................. 3 Biosynthesis of curacin A ............................................................................................................................. 5 Terminal double bond offloading ............................................................................................................. 5 Canonical sulfotransferases and thioesterases ...................................................................... 7 Other instances of ACP-­‐ST-­‐TE tridomains ................................................................................ 8 Chemistry related to ST-­‐TE olefin production ..................................................................... 13 ST-­‐TE olefin offloading as a chemical tool ............................................................................. 14 The lost haloalkane dehalogenase CurN/DmmA ................................................................ 15 Thesis overview .............................................................................................................................. 15 Chapter 2 Terminal Alkene Formation by the Thioesterase of Curacin A Biosynthesis: Structure of a Decarboxylating Thioesterase .................................. 17 Summary ........................................................................................................................................... 17 Introduction ..................................................................................................................................... 18 Experimental Procedures ........................................................................................................... 21 Crystallization. ............................................................................................................................................... 22 Results ............................................................................................................................................... 26 Discussion ......................................................................................................................................... 39 Conclusion. ...................................................................................................................................................... 42 
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2011
2011
Curacin A is a polyketide synthase (PKS)-non-ribosomal peptide synthetase-derived natural product with potent anticancer… Expand
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2009
2009
The cyanobacterial genus Lyngbya includes free-living, benthic, filamentous cyanobacteria that form periodic nuisance blooms in… Expand
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2005
2005
Curacin, die chlorhaltige Fraktion der milden Hydrolyse des Antibiotikums Curamycin, wurde durch ihre chemischen und… Expand
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1999
1999
Curacin A is a potent competitive inhibitor of colchicine binding to tubulin, and it inhibits the growth of tumor cells. We… Expand
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1998
1998
Curacin D is a novel brine shrimp toxic metabolite isolated from a Virgin Islands collection of the marine cyanobacterium Lyngbya… Expand
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1995
1995
Curacin A, the major lipid constituent of a strain of the marine cyanobacterium Lyngbya majuscula obtained off the coast of Cura… Expand
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