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Antitumor polyketide biosynthesis by an uncultivated bacterial symbiont of the marine sponge Theonella swinhoei.
Close related genes isolated from the highly complex metagenome of the marine sponge Theonella swinhoei, which is the source of the onnamides and theopederins, a group of polyketides that structurally resemble pederin are reported.
An environmental bacterial taxon with a large and distinct metabolic repertoire
Two phylotypes of the candidate genus ‘Entotheonella’ with genomes of greater than 9 megabases and multiple, distinct biosynthetic gene clusters co-inhabit the chemically and microbially rich marine sponge Theonella swinhoei.
Investigations of a neurotoxic oscillatorialean strain (Cyanophyceae) and its toxin. Isolation and characterization of homoanatoxin‐a
Experiments with rat phrenic nerve-hemidiaphragm preparations demonstrated that the physiological effects of homoanatoxin-a are related to those observed for d-tubocurarine.
Metagenome Mining Reveals Polytheonamides as Posttranslationally Modified Ribosomal Peptides
A ribosomal origin is demonstrated of the marine sponge–derived polytheonamides, exceptionally potent, giant natural-product toxins, which broadens the biosynthetic scope of ribosomally synthesized peptides and proteins and creates new opportunities for peptide and protein bioengineering.
Isolation of azaspiracid-2 from a marine sponge Echinoclathria sp. as a potent cytotoxin.
Gliotoxin analogues from a marine-derived fungus, Penicillium sp., and their cytotoxic and histone methyltransferase inhibitory activities.
Seven gliotoxin-related compounds were isolated from the fungus Penicillium sp. strain JMF034, obtained from deep sea sediments of Suruga Bay, Japan. These included two new metabolites,
Polytheonamides A and B, highly cytotoxic, linear polypeptides with unprecedented structural features, from the marine sponge, Theonella swinhoei.
Polytheonamides A and B are highly cytotoxic polypeptides with 48 amino acid residues isolated from the marine sponge, Theonella swinhoei, which resulted in the unprecedentedpolypeptide structure.
Targeting modular polyketide synthases with iteratively acting acyltransferases from metagenomes of uncultured bacterial consortia.
A phylogenetic approach to identify pederin-type PKS systems putatively involved in the biosynthesis of antitumour polyketides in the metagenomic DNA of beetles, sponges and their uncultivated bacterial symbionts is presented.
Ageladine A: an antiangiogenic matrixmetalloproteinase inhibitor from the marine sponge Agelas nakamurai.
A novel MMP inhibitor, ageladine A (1) with antiangiogenic activity was isolated from a marine sponge Agelas nakamurai. Structure 1 was determined by a combination of spectroscopic and chemical