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Antitumor polyketide biosynthesis by an uncultivated bacterial symbiont of the marine sponge Theonella swinhoei.
Bacterial symbionts have long been suspected to be the true producers of many drug candidates isolated from marine invertebrates. Sponges, the most important marine source of biologically activeExpand
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An environmental bacterial taxon with a large and distinct metabolic repertoire
Cultivated bacteria such as actinomycetes are a highly useful source of biomedically important natural products. However, such ‘talented’ producers represent only a minute fraction of the entire,Expand
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Investigations of a neurotoxic oscillatorialean strain (Cyanophyceae) and its toxin. Isolation and characterization of homoanatoxin‐a
A neurotoxic cyanophyte (Oscillatoriales) was characterized biologically and chemically with respect to toxic properties. The organism, identified as Oscillatoria formosa (Phormidium formosum [BoryExpand
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Isolation of azaspiracid-2 from a marine sponge Echinoclathria sp. as a potent cytotoxin.
Azaspiracid-2 was isolated from a marine sponge Echinoclathria sp. collected off Amami-Oshima as the predominant cytotoxic constituent. A combination of HPLC using ODS, GS320, and PhenylhexylExpand
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Metagenome Mining Reveals Polytheonamides as Posttranslationally Modified Ribosomal Peptides
Made and Modified The polytheonamides are 48-residue toxins derived from marine sponges that include 18 D-amino acids, as well as many other unusual amino acid modifications. Given the complexity,Expand
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Targeting modular polyketide synthases with iteratively acting acyltransferases from metagenomes of uncultured bacterial consortia.
Bacterial type I polyketide synthases (PKSs) produce a wide range of biomedically important secondary metabolites. These enzymes possess a modular structure that can be genetically re-engineered toExpand
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Exploring the chemistry of uncultivated bacterial symbionts: antitumor polyketides of the pederin family.
Symbiotic bacteria have long been proposed as being responsible for the production of numerous natural products isolated from invertebrate animals. However, systematic studies ofExpand
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Assessment of the marine toxins by monitoring the integrity of human intestinal Caco-2 cell monolayers.
The effects of marine substances with various cytotoxic mechanisms on the integrity of the human intestinal Caco-2 cell monolayer were examined by measuring the transepithelial electrical resistanceExpand
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Gliotoxin analogues from a marine-derived fungus, Penicillium sp., and their cytotoxic and histone methyltransferase inhibitory activities.
Seven gliotoxin-related compounds were isolated from the fungus Penicillium sp. strain JMF034, obtained from deep sea sediments of Suruga Bay, Japan. These included two new metabolites,Expand
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Copulation pheromone in the crab Telmessus cheiragonus (Brachyura : Decapoda)
Animals employ multi-step mate recognition processes to mate with their proper part- ners, for a given mating season. The signals used in mate recognition in Crustacea are fairly well stud- ied, butExpand
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