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Sharing and community curation of mass spectrometry data with Global Natural Products Social Molecular Networking
TLDR
In GNPS, crowdsourced curation of freely available community-wide reference MS libraries will underpin improved annotations and data-driven social-networking should facilitate identification of spectra and foster collaborations. Expand
Characterization of Cyanobacterial Hydrocarbon Composition and Distribution of Biosynthetic Pathways
TLDR
Hydrocarbon compositions of thirty-two strains of cyanob bacteria were characterized to reveal novel structural features and insights into hydrocarbon biosynthesis in cyanobacteria, which revealed new double bond and methyl group positions for a variety of strains. Expand
Marine natural products as anticancer drugs.
TLDR
This review highlights several marine natural products and their synthetic derivatives that are currently undergoing clinical evaluation as anticancer drugs. Expand
Oxylipin Profiling of the Hypersensitive Response in Arabidopsis thaliana
TLDR
The data presented suggest a role of enzymatically formed oxylipins, especially the octadecanoids and arabidopside E in race-specific resistance against bacterial pathogens. Expand
Lessons from the past and charting the future of marine natural products drug discovery and chemical biology.
TLDR
Understanding of how these agents are biosynthetically assembled has accelerated in recent years, especially through interdisciplinary approaches, and innovative manipulations and re-engineering of some of these gene clusters are yielding novel agents of enhanced pharmaceutical properties compared with the natural product. Expand
The structure of scytonemin, an ultraviolet sunscreen pigment from the sheaths of cyanobacteria
TLDR
The pigment scytonemin, the first shown to be an effective, photo-stable ultraviolet shield in prokaryotes, is a novel dimeric molecule of indolic and phenolic subunits and is known only from the sheaths enclosing the cells of cyanobacteria. Expand
Oxo-Phytodienoic Acid-Containing Galactolipids in Arabidopsis: Jasmonate Signaling Dependence1[W][OA]
TLDR
This study demonstrates that the synthesis of arabidopsides is mainly independent of the prokaryotic lipid biosynthesis pathway in the chloroplast, and reports inhibition of growth of the fungal necrotrophic pathogen Botrytis cinerea and in planta release of free jasmonates in a time frame that overlaps with the observed reduction of arABidopside levels. Expand
Metabolic engineering of lipid catabolism increases microalgal lipid accumulation without compromising growth
TLDR
The targeted knockdown of a multifunctional lipase/phospholipase/acyltransferase increased lipid yields without affecting growth in the diatom Thalassiosira pseudonana, demonstrating that targeted metabolic manipulations can be used to increase lipid accumulation in eukaryotic microalgae without compromising growth. Expand
The genomisotopic approach: a systematic method to isolate products of orphan biosynthetic gene clusters.
TLDR
A "genomisotopic approach," which employs a combination of genomic sequence analysis and isotope-guided fractionation to identify unknown compounds synthesized from orphan gene clusters containing nonribosomal peptide synthetases, resulted in the discovery of orfamide A, founder of a group of bioactive cyclic lipopeptides. Expand
Structure and biosynthesis of the jamaicamides, new mixed polyketide-peptide neurotoxins from the marine cyanobacterium Lyngbya majuscula.
TLDR
A screening program for bioactive compounds from marine cyanobacteria led to the isolation of jamaicamides A-C, a novel and highly functionalized lipopeptide containing an alkynyl bromide, vinyl chloride, beta-methoxy eneone system, and pyrrolinone ring, giving insight into the mechanism by which this functional group is created. Expand
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