Sharing and community curation of mass spectrometry data with Global Natural Products Social Molecular Networking
In GNPS, crowdsourced curation of freely available community-wide reference MS libraries will underpin improved annotations and data-driven social-networking should facilitate identification of spectra and foster collaborations.
Characterization of Cyanobacterial Hydrocarbon Composition and Distribution of Biosynthetic Pathways
Hydrocarbon compositions of thirty-two strains of cyanob bacteria were characterized to reveal novel structural features and insights into hydrocarbon biosynthesis in cyanobacteria, which revealed new double bond and methyl group positions for a variety of strains.
Marine natural products as anticancer drugs.
- T. L. Simmons, Eric H. Andrianasolo, K. McPhail, P. Flatt, W. Gerwick
- Chemistry, BiologyMolecular Cancer Therapeutics
- 1 February 2005
This review highlights several marine natural products and their synthetic derivatives that are currently undergoing clinical evaluation as anticancer drugs.
Metabolic engineering of lipid catabolism increases microalgal lipid accumulation without compromising growth
- Emily M. Trentacoste, R. Shrestha, W. Gerwick
- Biology, EngineeringProceedings of the National Academy of Sciences
- 18 November 2013
The targeted knockdown of a multifunctional lipase/phospholipase/acyltransferase increased lipid yields without affecting growth in the diatom Thalassiosira pseudonana, demonstrating that targeted metabolic manipulations can be used to increase lipid accumulation in eukaryotic microalgae without compromising growth.
Lessons from the past and charting the future of marine natural products drug discovery and chemical biology.
Oxylipin Profiling of the Hypersensitive Response in Arabidopsis thaliana
- M. Andersson, M. Hamberg, M. Ellerström
- Biology, Environmental ScienceJournal of Biological Chemistry
- 20 October 2006
The data presented suggest a role of enzymatically formed oxylipins, especially the octadecanoids and arabidopside E in race-specific resistance against bacterial pathogens.
The structure of scytonemin, an ultraviolet sunscreen pigment from the sheaths of cyanobacteria
The pigment scytonemin, the first shown to be an effective, photo-stable ultraviolet shield in prokaryotes, is a novel dimeric molecule of indolic and phenolic subunits and is known only from the sheaths enclosing the cells of cyanobacteria.
Minimum Information about a Biosynthetic Gene cluster.
This work proposes the Minimum Information about a Biosynthetic Gene cluster (MIBiG) data standard, to facilitate consistent and systematic deposition and retrieval of data on biosynthetic gene clusters.
The genomisotopic approach: a systematic method to isolate products of orphan biosynthetic gene clusters.
Oxo-Phytodienoic Acid-Containing Galactolipids in Arabidopsis: Jasmonate Signaling Dependence1[W][OA]
This study demonstrates that the synthesis of arabidopsides is mainly independent of the prokaryotic lipid biosynthesis pathway in the chloroplast, and reports inhibition of growth of the fungal necrotrophic pathogen Botrytis cinerea and in planta release of free jasmonates in a time frame that overlaps with the observed reduction of arABidopside levels.