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crenolanib

Known as: [1-[2-[5-(3-Methyloxetan-3-ylmethoxy)benzimidazol-1-yl]quinolin-8-yl]piperidin-4-yl]amine, PDGFR Inhibitor CP-868596, PDGFR inhibitor CP-868,596 
An orally bioavailable benzimidazole targeting the platelet-derived growth factor receptor (PDGFR) subtypes alpha and beta and FMS-related tyrosine… Expand
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
FLT3 mutations are prevalent in AML patients and confer poor prognosis. Crenolanib, a potent type I pan-FLT3 inhibitor, is… Expand
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2018
2018
FMS-like tyrosine kinase 3 (FLT3) is a transmembrane protein expressed on normal hematopoietic stem and progenitor cells (HSC… Expand
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2017
2017
Background:While midostaurin, a pan-kinase inhibitor, represents an advance in the treatment of newly diagnosed patients Methods… Expand
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Highly Cited
2015
Highly Cited
2015
Activating mutations in FLT3 occur in ~30% of adult acute myeloid leukemia, primarily consisting of internal tandem duplication… Expand
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Highly Cited
2014
Highly Cited
2014
Mutations of the type III receptor tyrosine kinase FLT3 occur in approximately 30% of acute myeloid leukemia patients and lead to… Expand
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Highly Cited
2014
Highly Cited
2014
Introduction FLT3-ITD (Internal tandem duplication) and FLT3-TKD (tyrosine kinase domain, D835) mutations are frequently seen in… Expand
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Highly Cited
2014
Highly Cited
2014
Significance Rapid evolution of drug resistance associated with secondary kinase domain (KD) mutations is the best characterized… Expand
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Highly Cited
2013
Highly Cited
2013
FLT3 kinase internal tandem duplication (ITD) mutations are common in acute myeloid leukemia (AML) and are associated with poor… Expand
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Highly Cited
2012
Highly Cited
2012
Purpose: To determine the potential of crenolanib, a potent inhibitor of PDGFRA, to treat malignancies driven by mutant PDGFRA… Expand
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