crenolanib

Known as: [1-[2-[5-(3-Methyloxetan-3-ylmethoxy)benzimidazol-1-yl]quinolin-8-yl]piperidin-4-yl]amine, PDGFR Inhibitor CP-868596, PDGFR inhibitor CP-868,596 
An orally bioavailable benzimidazole targeting the platelet-derived growth factor receptor (PDGFR) subtypes alpha and beta and FMS-related tyrosine… (More)

Topic mentions per year

Topic mentions per year

2010-2018
0520102018

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
Systemic sclerosis (SSc) is a multi-organ fibrotic disease with few treatment options. Activated fibroblasts are the key effector… (More)
Is this relevant?
2014
2014
Mutations of the type III receptor tyrosine kinase FLT3 occur in approximately 30% of acute myeloid leukemia patients and lead to… (More)
  • table 1
  • figure 1
  • figure 2
  • figure 3
  • figure 4
Is this relevant?
2014
2014
Tyrosine kinase inhibitors (TKIs) represent transformative therapies for several malignancies. Two critical features necessary… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
2014
2014
Platelet-derived growth factor (PDGF) and its receptors (PDGFR), including PDGFRα and PDGFRβ, play important roles in… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
Is this relevant?
2013
2013
FLT3 kinase internal tandem duplication (ITD) mutations are common in acute myeloid leukemia (AML) and are associated with poor… (More)
  • table 1
Is this relevant?
2013
2013
In this issue of Blood, Zimmerman and colleagues demonstrate that the tyrosine kinase inhibitor (TKI) crenolanib effectively… (More)
Is this relevant?
2013
2013
PURPOSE Platelet-derived growth factor receptor α (PDGFRA) is a target for tyrosine kinase inhibitor (TKI)-based targeted therapy… (More)
  • table 1
  • table 2
  • figure 1
  • table 3
  • figure 2
Is this relevant?
Highly Cited
2012
Highly Cited
2012
PURPOSE To determine the potential of crenolanib, a potent inhibitor of PDGFRA, to treat malignancies driven by mutant PDGFRA… (More)
  • table 1
  • table 2
  • figure 1
  • table 3
  • figure 2
Is this relevant?
2011
2011
10012 Background: 8-10% of gastrointestinal stromal tumors (GIST) have activating mutations of the platelet-derived growth factor… (More)
Is this relevant?
2010
2010
Background:Tumoural interstitial hypertension, possibly modulated by platelet-derived and vascular endothelial growth factor… (More)
  • table 1
  • table 2
  • table 3
  • figure 1
  • table 4
Is this relevant?