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compactin

Known as: 6-demethylmevinolin, 7-(1,2,6,7,8,8a-hexahydro-2-methyl-8- (2-methylbutyryloxy)naphthyl)-3-hydroxyheptan-5-olide, Mevastatin 
An HMG-CoA reductase inhibitor that was initially isolated from the mold Pythium ultimum. Mevastatin was the first statin to enter clinical trials.
National Institutes of Health

Related topics

Related topics

7 relations

Broader (5)

Anti-Bacterial AgentsAnticholesteremic AgentsAntifungal AgentsHydroxymethylglutaryl-CoA Reductase Inhibitors

Narrower (1)

ML 236B
analogs & derivatives

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2014
2014
[Overexpression of LaeA enhances mevastatin production and reduces sporulation of Penicillium citrinum].
OBJECTIVE To study the regulation of laeA overexpression on mevastatin production and sporulation in Penicillium citrinum… 
1996
1996
Novel synthetic strategy for HMG-CoA reductase inhibitors
Abstract 
Highly Cited
1986
Highly Cited
1986
3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors. 3. 7-(3,5-Disubstituted [1,1'-biphenyl]-2-yl)-3,5-dihydroxy-6-heptenoic acids and their lactone derivatives.
The syntheses of a series of 7-(3,5-disubstituted [1,1'-bephenyl]-2-yl)-3,5-dihydroxy-6-heptenoic acids and their lactones are… 
1986
1986
Microbial conversion of compactin (ML-236B) to ML-236A.
Approximately 1,600 fungal strains were tested for ability to convert compactin (ML-236B) to ML-236A and Emericella unguis IFO… 
1985
1985
Microbial phosphorylation of compactin (ML-236B) and related compounds.
Several fungal strains were found to convert compactin (ML-236B) to 5'-phosphocompactic acid. The product was isolated by solvent… 
1984
1984
Combined drug therapy--cholestyramine and compactin--for familial hypercholesterolemia.
Combined drug therapy with cholestyramine and compactin was found to be extremely effective against heterozygous cases of… 
1983
1983
Taxonomy of actinomycetes capable of hydroxylation of ML-236B (compactin).
Three actinomycetes having capability of 3 beta-hydroxylation of ML-236B were isolated from soil samples collected in Australia… 
1983
1983
The role of substrate supply in the regulation of cholesterol biosynthesis in rat hepatocytes.
1. Compactin, (-)-hydroxycitrate and dexamethasone gave rise to a decrease in the rate of cholesterol production in hepatocytes… 
1983
1983
Progesterone production by hamster granulosa and luteal cells during short-term incubation. Effects of lipoproteins, compactin and 25-hydroxycholesterol.
Granulosa and luteal cells from immature, hormone-primed hamsters increased progesterone production in response to luteinizing… 
1980
1980
The preparation and purification of isolated rat corpus-luteum cells and their use in studying the relationship between cholesterol biosynthesis and the lutropin-stimulated formation of progesterone.
Isolated luteal cells, prepared from superovulated rat ovaries by digestion with collagenase, were subjected to density-gradient…