compactin

Known as: 6-demethylmevinolin, 7-(1,2,6,7,8,8a-hexahydro-2-methyl-8- (2-methylbutyryloxy)naphthyl)-3-hydroxyheptan-5-olide, Mevastatin 
An HMG-CoA reductase inhibitor that was initially isolated from the mold Pythium ultimum. Mevastatin was the first statin to enter clinical trials.
National Institutes of Health

Papers overview

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Highly Cited
2005
Highly Cited
2005
BACKGROUND Although 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) are known to modulate endothelial… (More)
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Highly Cited
2003
Highly Cited
2003
Endothelial progenitor cells (EPCs) play an important role in postnatal neovascularization of ischemic tissue. Ex vivo expansion… (More)
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Highly Cited
2002
Highly Cited
2002
3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) exert potent vasculoprotective effects. However, the… (More)
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Highly Cited
2000
Highly Cited
2000
Bone morphogenetic protein (BMP)-2, a member of the BMP family, plays an important role in osteoblast differentiation and bone… (More)
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Highly Cited
1998
Highly Cited
1998
The mechanism by which 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase inhibitors increase endothelial nitric oxide synthase (eNOS… (More)
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Highly Cited
1998
Highly Cited
1998
Bisphosphonates are currently the most important class of antiresorptive drugs used for the treatment of metabolic bone diseases… (More)
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Highly Cited
1995
Highly Cited
1995
Two sterol regulatory element-binding proteins (SREBPs, designated SREBP-1 and SREBP-2), each approximately 1150 amino acids in… (More)
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Highly Cited
1983
Highly Cited
1983
In subject with heterozygous familial hypercholesterolemia (FH), a 50% deficiency of receptors for plasma low density lipoprotein… (More)
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Highly Cited
1980
Highly Cited
1980
Mevinolin, a fungal metabolite, was isolated from cultures of Aspergillus terreus. The structure and absolute configuration of… (More)
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Highly Cited
1978
Highly Cited
1978
The two compounds compactin and ML-236B are identical fungal metabolites isolated from strains of Penicilliunz brevicompactum and… (More)
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