Skip to search formSkip to main contentSkip to account menu

compactin

Known as: 6-demethylmevinolin, 7-(1,2,6,7,8,8a-hexahydro-2-methyl-8- (2-methylbutyryloxy)naphthyl)-3-hydroxyheptan-5-olide, Mevastatin 
An HMG-CoA reductase inhibitor that was initially isolated from the mold Pythium ultimum. Mevastatin was the first statin to enter clinical trials.
National Institutes of Health

Related topics

Related topics

7 relations

Broader (5)

Anti-Bacterial AgentsAnticholesteremic AgentsAntifungal AgentsHydroxymethylglutaryl-CoA Reductase Inhibitors

Narrower (1)

ML 236B
analogs & derivatives

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2010
Highly Cited
2010
Chronic cholesterol depletion using statin impairs the function and dynamics of human serotonin(1A) receptors.
Statins are potent inhibitors of HMG-CoA reductase, the key rate-limiting enzyme in cholesterol biosynthesis, and are some of the… 
Highly Cited
2006
Highly Cited
2006
Cholesterol depletion induces autophagy.
Highly Cited
2005
Highly Cited
2005
FOXO‐dependent expression of the proapoptotic protein Bim: pivotal role for apoptosis signaling in endothelial progenitor cells
Endothelial progenitor cells (EPCs) contribute to postnatal neovascularization. Risk factors for coronary artery disease reduce… 
Highly Cited
2005
Highly Cited
2005
RMD: a rice mutant database for functional analysis of the rice genome
Rice Mutant Database (RMD, ) is an archive for collecting, managing and searching information of the T-DNA insertion mutants… 
Highly Cited
2005
Highly Cited
2005
Effector γδ T cells and tumor cells as immune targets of zoledronic acid in multiple myeloma
The aim of this study was to investigate the in vitro immunomodulatory effects of zoledronic acid (Zol) on peripheral blood Vγ9/V… 
Highly Cited
1998
Highly Cited
1998
The bisphosphonate incadronate (YM175) causes apoptosis of human myeloma cells in vitro by inhibiting the mevalonate pathway.
It has recently been suggested that bisphosphonates may have direct antitumor effects in vivo, in addition to their therapeutic… 
Highly Cited
1995
Highly Cited
1995
Coronal leakage: effects of smear layer, obturation technique, and sealer.
Highly Cited
1983
Highly Cited
1983
Reduction of serum cholesterol in heterozygous patients with familial hypercholesterolemia. Additive effects of compactin and cholestyramine.
We studied the effects of the bile acid sequestrant cholestyramine, alone and in combination with the experimental agent… 
Highly Cited
1983
Highly Cited
1983
The dual role of mevalonate in the cell cycle.
Highly Cited
1981
Highly Cited
1981
The effects of subfractions of high density lipoprotein on cholesterol efflux from cultured fibroblasts. Regulation of low density lipoprotein receptor activity.
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)