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ML 236B

Known as: ML 236 B, ML-236B, ML236B 
National Institutes of Health

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Broader (2)

Lovastatincompactin

Papers overview

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2008
2008
The statins in preventive cardiology.
By inhibiting the biosynthesis of endogenous cholesterol, the statin drugs lower elevated blood cholesterol levels much more… 
Review
1996
Review
1996
Biochemical and molecular approaches for production of pravastatin, a potent cholesterol-lowering drug.
1986
1986
Structure elucidation of the bioactive metabolites of ML-236B (mevastatin) isolated from dog urine.
Two active metabolites of ML-236B, 4β, 6α-dihydroxy ML-236B (M3, 2), and 3β-hydroxy ML-236B (M4, 3), were isolated from the urine… 
1986
1986
Microbial conversion of compactin (ML-236B) to ML-236A.
Approximately 1,600 fungal strains were tested for ability to convert compactin (ML-236B) to ML-236A and Emericella unguis IFO… 
1985
1985
Microbial phosphorylation of compactin (ML-236B) and related compounds.
Several fungal strains were found to convert compactin (ML-236B) to 5'-phosphocompactic acid. The product was isolated by solvent… 
1985
1985
Microbial hydroxylation of compactin (ML-236B) and monacolin K.
The Basidiomycete Schizophyllum commune was found to transform compactin (ML-236B) to 8a-hydroxycompactin. This compound was… 
1984
1984
Blocking 3-hydroxy-3-methylglutaryl coenzyme A reductase with ML-236B enhances the plasma cortisol response to adrenocorticotropin in patients with hypercholesterolemia.
The effect of ML-236B, a specific inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase, on serum lipids and plasma… 
1983
1983
Taxonomy of actinomycetes capable of hydroxylation of ML-236B (compactin).
Three actinomycetes having capability of 3 beta-hydroxylation of ML-236B were isolated from soil samples collected in Australia… 
1982
1982
Chinese hamster cell mutant resistant to ML236B (Compactin) is defective in endocytosis of low-density lipo-protein
A fungal metabolite, ML236B (Compactin), isolated from Penicillium citrinum, is a specific inhibitor of 3-hydroxy-3… 
1981
1981
Hypolipidemic effects of CS-500 (ML-236B) in WHHL-rabbit, a heritable animal model for hyperlipidemia.
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